Molecular complexes of ketaconazole and oxatomide with p-chloranil: Spectroscopic and spectrofluorimetric studies

被引：10

作者：

Balraj, C. ^{[1
]}

Ganesh, K. ^{[1
]}

Elango, K. P. ^{[1
]}

机构：

[1] Deemed Univ, Dept Chem, Gandhigram Rural Inst, Gandhigram 624302, India

来源：

SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY | 2011年 / 79卷 / 05期

关键词：

Charge transfer complex; Ketaconazole; Oxatomide; Chloranil; Fluorescence study; Kinetics; CHARGE-TRANSFER COMPLEXES; THERAPEUTIC EFFICACY; ACCEPTORS; FEEDS; KETOCONAZOLE;

D O I：

10.1016/j.saa.2011.04.033

中图分类号：

O433 [光谱学];

学科分类号：

0703 ; 070302 ;

摘要：

The molecular complexes of the donors ketaconazole (KTZ) and oxatomide (OXA) drugs with 2,3,5,6-tetrachloro-1,4-benzoquinone (p-chloranil, p-CHL) have been investigated spectroscopically (UV-vis, FT-IR and (1)H NMR) and spectrofluorimetrically in different solvents and temperatures. The stoichiometry of the complexes was found to be 1:1. The data are discussed in terms of formation constant, molar extinction coefficient, oscillator strength, dipole moment, ionization potential, dissociation energy and thermodynamic parameters. The results indicated that the formation of molecular complex is spontaneous and endothermic. The fluorescence quenching studies indicated that the interaction of the donors is spontaneous and the fluorescence quenching increased with an increase in the intensity of complexation with the acceptor. (C) 2011 Elsevier B.V. All rights reserved.

引用

页码：1137 / 1144

页数：8

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