Microengineered Vascular Systems for Drug Development

被引：10
作者：
Hovell, Candice M. [1 ]
Sei, Yoshitaka J. [2 ]
Kim, YongTae [1 ,2 ,3 ,4 ]
机构：
[1] Georgia Inst Technol, Wallace H Coulter Dept Biomed Engn, Atlanta, GA 30318 USA
[2] Georgia Inst Technol, George W Woodruff Sch Mech Engn, Atlanta, GA 30318 USA
[3] Georgia Inst Technol, Inst Elect & Nanotechnol, Atlanta, GA 30318 USA
[4] Georgia Inst Technol, Parker H Petit Inst Bioengn & Biosci, Atlanta, GA 30318 USA
来源：
JALA | 2015年 / 20卷 / 03期
关键词：
microfluidics; microtechnology; nanotechnology; lab on a chip; fabrication; nanobiotech; BLOOD-BRAIN-BARRIER; IN-VITRO MODELS; MICROFLUIDIC PLATFORM; MOUSE MODELS; HUMAN LIVER; CHIP; POINT; INTEGRATION; DELIVERY; DEVICE;
D O I：
10.1177/2211068214560767
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
Recent advances in microfabrication technologies and advanced biomaterials have allowed for the development of in vitro platforms that recapitulate more physiologically relevant cellular components and function. Microengineered vascular systems are of particular importance for the efficient assessment of drug candidates to physiological barriers lining microvessels. This review highlights advances in the development of microengineered vascular structures with an emphasis on the potential impact on drug delivery studies. Specifically, this article examines the development of models for the study of drug delivery to the central nervous system and cardiovascular system. We also discuss current challenges and future prospects of the development of microengineered vascular systems.
引用
收藏
页码：251 / 258
页数：8
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