Extracellular vesicles in kidney transplantation: a state-of-the-art review

被引：18
作者：
Ashcroft, James [1 ,2 ]
Leighton, Philippa [1 ,2 ]
Elliott, Tegwen R. [1 ,2 ]
Hosgood, Sarah A. [1 ,2 ,3 ]
Nicholson, Michael L. [1 ,2 ,3 ]
Kosmoliaptsis, Vasilis [1 ,2 ,3 ]
机构：
[1] Univ Cambridge, Dept Surg, Cambridge CB2 0QQ, England
[2] Addenbrookes Hosp, Natl Inst Hlth Res, Cambridge Biomed Res Ctr, Cambridge, England
[3] Univ Cambridge, Natl Inst Hlth Res, Blood & Transplant Res Unit Organ Donat & Transpl, Cambridge, England
来源：
KIDNEY INTERNATIONAL | 2022年 / 101卷 / 03期
关键词：
extracellular vesicles; graft survival; kidney transplantation; ISCHEMIA-REPERFUSION INJURY; MESENCHYMAL STROMAL CELLS; URINARY EXOSOMES; PROTEOMICS; BIOMARKER; PROTECT; EXPRESSION; PERFUSION; SURVIVAL; MARKERS;
D O I：
10.1016/j.kint.2021.10.038
中图分类号：
R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];
学科分类号：
1002 ; 100201 ;
摘要：
Kidney transplantation is the optimal treatment for patients with kidney failure; however, early detection and timely treatment of graft injury remain a challenge. Precise and noninvasive techniques of graft assessment and innovative therapeutics are required to improve kidney transplantation outcomes. Extracellular vesicles (EVs) are lipid bilayer-delimited particles with unique biosignatures and immunomodulatory potential, functioning as intermediaries of cell signalling. Promising evidence exists for the potential of EVs to develop precision diagnostics of graft dysfunction, and prognostic biomarkers for clinician decision making. The inherent targeting characteristics of EVs and their low immunogenic and toxicity profiles combined with their potential as vehicles for drug delivery make them ideal targets for development of therapeutics to improve kidney transplant outcomes. In this review, we summarize the current evidence for EVs in kidney transplantation, discuss common methodological principles of EV isolation and characterization, explore upcoming innovative approaches in EV research, and discuss challenges and opportunities to enable translation of research findings into clinical practice.
引用
收藏
页码：485 / 497
页数：13
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