Bioactive neo-Clerodane Diterpenoids from the Whole Plants of Ajuga ciliata Bunge

被引：43

作者：

Guo, Ping ^{[1
,2
,3
]}

Li, Yushan ^{[3
]}

Xu, Jing ^{[1
,2
]}

Liu, Cuizhou ^{[1
,2
]}

Ma, Yonggang ^{[1
,2
]}

Gue, Yuanqiang ^{[1
,2
]}

机构：

[1] Nankai Univ, Coll Pharm, Tianjin 300071, Peoples R China

[2] Nankai Univ, Tianjin Key Lab Mol Drug Res, Tianjin 300071, Peoples R China

[3] Shenyang Pharmaceut Univ, Sch Tradit Chinese Materia Med, Shenyang 110016, Peoples R China

来源：

JOURNAL OF NATURAL PRODUCTS | 2011年 / 74卷 / 07期

关键词：

IRIDOID GLUCOSIDE; PHYTOECDYSTEROIDS; WITHANOLIDES; CONSTITUENTS; GLYCOSIDES; FAMILY;

D O I：

10.1021/np2001557

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Ten new neo-clerodane diterpenes, ajugaciliatins A-J (1-5, 8-12), along with 17 known analogues (6, 7, 13-27) were isolated from the whole plants of Ajuga ciliata Bunge. Their structures were elucidated by spectroscopic data analysis (IR, ESIMS, HRESIMS, 1D and 2D NMR), and the configuration of 1 was confirmed by X-ray crystallography. All of the compounds were assessed for neuroprotective effects against MPP+-induced neuronal cell death in dopaminergic neuroblastoma SH-SY5Y cells. Compounds 2, 6, 7, 9, 10, 15-17, 19, and 20 exhibited moderate neuroprotective effects.

引用

页码：1575 / 1583

页数：9

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