Targeting Intracellular Pathogenic Bacteria Through N-Terminal Modification of Cationic Amphiphilic Polyproline Helices

被引：9

作者：

Dietsche, Thomas A. ^{[1
]}

Eldesouky, Hassan E. ^{[2
]}

Zeiders, Samantha M. ^{[1
]}

Seleem, Mohamed N. ^{[2
]}

Chmielewski, Jean ^{[1
]}

机构：

[1] Purdue Univ, Dept Chem, W Lafayette, IN 47907 USA

[2] Purdue Univ, Dept Comparat Pathobiol, W Lafayette, IN 47907 USA

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2020年 / 85卷 / 11期

基金：

美国国家科学基金会;

关键词：

ACINETOBACTER-BAUMANNII; NANOPARTICLES; PEPTIDES;

D O I：

10.1021/acs.joc.0c00871

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Intracellular pathogens can thrive within mammalian cells and are inaccessible to many antimicrobial agents. Herein, we present a facile method of enhancing the cell penetrating and antibacterial properties of cationic amphiphilic polyproline helices (CAPHs) with modifications to the hydrophobic moiety at the N-terminus. These altered CAPHs display superior cell penetration within macrophage cells, and in some cases, minimal cytotoxicity. Furthermore, one CAPH, Pentyl-P14 exhibited excellent antibacterial activity against multiple strains of pathogenic bacteria and promoted the clearance of intracellular Shigella within macrophages.

引用

页码：7468 / 7475

页数：8

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