Post-translational modifications on mitochondrial metabolic enzymes in cancer

被引:34
作者
Peng, Yunhua [1 ]
Liu, Huadong [1 ]
Liu, Jiankang [1 ,2 ]
Long, Jiangang [1 ]
机构
[1] Xi An Jiao Tong Univ, Ctr Mitochondrial Biol & Med, Sch Life Sci & Technol, Key Lab Biomed Informat Engn,Minist Educ, Xian 710049, Peoples R China
[2] Univ Hlth & Rehabil Sci, Qingdao 266071, Peoples R China
基金
中国国家自然科学基金; 中国博士后科学基金;
关键词
TCA cycle; OXPHOS; Post-translational modification; Metabolism; Mitochondrial biogenesis; Mitophagy; E3 UBIQUITIN LIGASE; CELL-CYCLE; TRANSCRIPTIONAL COACTIVATOR; PYRUVATE-DEHYDROGENASE; CITRATE SYNTHASE; IDH2; MUTATIONS; PROTEIN-KINASE; HUMAN METTL12; HUMAN TFAM; PROMOTES;
D O I
10.1016/j.freeradbiomed.2021.12.264
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Mitochondrion is the powerhouse of the cell. The research of nearly a century has expanded our understanding of mitochondrion, far beyond the view that mitochondrion is an important energy generator of cells. During the initiation, growth and survival of tumor cells, significant mitochondrial metabolic changes have taken place in the important enzymes of respiratory chain and tricarboxylic acid cycle, mitochondrial biogenesis and dynamics, oxidative stress regulation and molecular signaling. Therefore, mitochondrial metabolic proteins are the key mediators of tumorigenesis. Post-translational modification is the molecular switch that regulates protein function. Understanding how these mitochondria-related post-translational modification function during tumorigenesis will bring new ideas for the next generation of cancer treatment.
引用
收藏
页码:11 / 23
页数:13
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