Protective effects of resveratrol on calcium-induced oxidative stress in rat heart mitochondria

被引：16
|
作者：
Gutierrez-Perez, Areli
Cortes-Rojo, Christian
Noriega-Cisneros, Ruth
Calderon-Cortes, Elizabeth [2 ]
Manzo-Avalos, Salvador
Clemente-Guerrero, Monica
Godinez-Hernandez, Daniel
Boldogh, Istvan [3 ]
Saavedra-Molina, Alfredo [1 ,3 ]
机构：
[1] Univ Michoacana, Inst Invest Quim Biol, Morelia, Michoacan, Mexico
[2] Univ Michoacana, Fac Enfermeria, Morelia, Michoacan, Mexico
[3] Univ Texas Med Branch Galveston, Sch Med, Galveston, TX USA
来源：
JOURNAL OF BIOENERGETICS AND BIOMEMBRANES | 2011年 / 43卷 / 02期
关键词：
Cardioprotection; Resveratrol; Mitochondria; Oxidative stress; Calcium-overload; ELECTRON-TRANSPORT CHAIN; UNCOUPLING PROTEINS; HYPERTENSIVE-RATS; DYSFUNCTION; INHIBITION; DAMAGE; BRAIN; CELLS;
D O I：
10.1007/s10863-011-9349-4
中图分类号：
Q6 [生物物理学];
学科分类号：
071011 ;
摘要：
Trans-resveratrol is a nutraceutical with known antioxidant, anti-inflammatory, cardioprotective, and anti-apoptotic properties. The aim of this study was to evaluate the effects of resveratrol on heart mitochondria. Resveratrol significantly decreased Fe2+ + ascorbate oxidant system-induced lipid peroxide levels, preserved physiological levels of glutathione, and increased nitric oxide (NO) levels in mitochondria. Under calcium-mediated stress, there was a 2.7-fold increase in the NO levels, and a mild decoupling in the mitochondrial respiratory chain. These results provide a mechanism for and support the beneficial effects of resveratrol under pathological conditions induced by oxidative stress and calcium overload. In addition, these findings underscore the usefulness of resveratrol in the prevention of cardiovascular diseases.
引用
收藏
页码：101 / 107
页数：7
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