Mechanisms underlying combined action of clonidine and local anesthetics

被引：0
|
作者：
Ponomarev, VP [1 ]
Galenko-Yaroshevskii, AP
Dukhanin, AS
Anisimova, VA
机构：
[1] Russian Acad Med Sci, Krasnodar Res Ctr, Krasnodar Krai Adm, Moscow, Russia
[2] Russian State Med Univ, Moscow 117437, Russia
[3] Rostov State Univ, Inst Organ Chem, Rostov Na Donu 344006, Russia
来源：
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 2003年 / 136卷 / 01期
关键词：
local anesthetics; clonidine; alpha(2)-adrenoceptors; imidazoline receptors; human platelets;
D O I：
10.1023/A:1026088813307
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
We studied the mechanisms of combined action of clonidine and local anesthetics amethocaine and imidazo-benzimidazole derivative RU-1117. In contrast to amethocaine, RU-1117 in therapeutic concentrations binds to imidazoline receptors and, to a lesser extent, to alpha(2A)-adrenoceptors on human platelets. Clonidine and RU-1117 produce opposite effects on platelet aggregation induced by ADP in low concentrations. Our results suggest that the pharmacodynamic interaction of clonidine and RU-1117 is associated with their ability to activate the imidazolinergic system.
引用
收藏
页码：53 / 55
页数：3
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