Mechanisms underlying combined action of clonidine and local anesthetics

被引：0
|
作者：
Ponomarev, VP [1 ]
Galenko-Yaroshevskii, AP
Dukhanin, AS
Anisimova, VA
机构：
[1] Russian Acad Med Sci, Krasnodar Res Ctr, Krasnodar Krai Adm, Moscow, Russia
[2] Russian State Med Univ, Moscow 117437, Russia
[3] Rostov State Univ, Inst Organ Chem, Rostov Na Donu 344006, Russia
来源：
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 2003年 / 136卷 / 01期
关键词：
local anesthetics; clonidine; alpha(2)-adrenoceptors; imidazoline receptors; human platelets;
D O I：
10.1023/A:1026088813307
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
We studied the mechanisms of combined action of clonidine and local anesthetics amethocaine and imidazo-benzimidazole derivative RU-1117. In contrast to amethocaine, RU-1117 in therapeutic concentrations binds to imidazoline receptors and, to a lesser extent, to alpha(2A)-adrenoceptors on human platelets. Clonidine and RU-1117 produce opposite effects on platelet aggregation induced by ADP in low concentrations. Our results suggest that the pharmacodynamic interaction of clonidine and RU-1117 is associated with their ability to activate the imidazolinergic system.
引用
收藏
页码：53 / 55
页数：3
相关论文
共 50 条
  • [21] MOLECULAR MECHANISMS OF ACTION OF GENERAL-ANESTHETICS
    DODSON, BA
    MOSS, J
    MOLECULAR AND CELLULAR BIOCHEMISTRY, 1984, 64 (02) : 97 - 103
  • [22] ACTION OF LOCAL ANESTHETICS ON COUPLING SYSTEMS IN MUSCLE
    BIANCHI, CP
    BOLTON, TC
    JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 1967, 157 (02): : 388 - &
  • [23] COMPETITIVE NATURE OF ACTION OF ACETYLCHOLINE AND LOCAL ANESTHETICS
    HIGMAN, HB
    BARTELS, E
    BIOCHIMICA ET BIOPHYSICA ACTA, 1961, 54 (03) : 543 - &
  • [24] Local anesthetics take a central action in analgesia
    Zeilhofer, Hanns Ulrich
    Schmelz, Martin
    PAIN, 2015, 156 (09) : 1579 - 1580
  • [25] LOCAL-ANESTHETICS - ACTION, METABOLISM, AND TOXICITY
    DIFAZIO, CA
    OTOLARYNGOLOGIC CLINICS OF NORTH AMERICA, 1981, 14 (03) : 515 - 519
  • [26] ACTION OF LOCAL ANESTHETICS ON THE ACTION POTENTIAL OF ISOLATED, PERIPHERAL NERVE
    RUD, J
    ACTA PHYSIOLOGICA SCANDINAVICA, 1957, 42 : 120 - 121
  • [27] The action of local anesthetics on the heart in vitro.
    Dabarakis, N
    Tsirlis, A
    Parissis, N
    Spyridopoulos, G
    JOURNAL OF DENTAL RESEARCH, 2003, 82 : 495 - 495
  • [28] EFFECT OF NERVE SHEATH ON ACTION OF LOCAL ANESTHETICS
    RITCHIE, JM
    RITCHIE, B
    GREENGARD, P
    JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 1965, 150 (01): : 160 - +
  • [29] BIOCHEMICAL ASPECTS OF THE ACTION OF LOCAL-ANESTHETICS
    NAZARENKO, VI
    BELIK, YV
    UKRAINSKII BIOKHIMICHESKII ZHURNAL, 1985, 57 (05): : 85 - 100
  • [30] Concerning the action of local anesthetics on striated muscle
    Kubota, S
    Macht, DI
    JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 1919, 13 (01): : 31 - 44
12345