Mechanisms underlying combined action of clonidine and local anesthetics

被引：0
|
作者：
Ponomarev, VP [1 ]
Galenko-Yaroshevskii, AP
Dukhanin, AS
Anisimova, VA
机构：
[1] Russian Acad Med Sci, Krasnodar Res Ctr, Krasnodar Krai Adm, Moscow, Russia
[2] Russian State Med Univ, Moscow 117437, Russia
[3] Rostov State Univ, Inst Organ Chem, Rostov Na Donu 344006, Russia
来源：
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 2003年 / 136卷 / 01期
关键词：
local anesthetics; clonidine; alpha(2)-adrenoceptors; imidazoline receptors; human platelets;
D O I：
10.1023/A:1026088813307
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
We studied the mechanisms of combined action of clonidine and local anesthetics amethocaine and imidazo-benzimidazole derivative RU-1117. In contrast to amethocaine, RU-1117 in therapeutic concentrations binds to imidazoline receptors and, to a lesser extent, to alpha(2A)-adrenoceptors on human platelets. Clonidine and RU-1117 produce opposite effects on platelet aggregation induced by ADP in low concentrations. Our results suggest that the pharmacodynamic interaction of clonidine and RU-1117 is associated with their ability to activate the imidazolinergic system.
引用
收藏
页码：53 / 55
页数：3
相关论文
共 50 条
  • [1] Mechanisms Underlying Combined Action of Clonidine and Local Anesthetics
    V. P. Ponomarev
    A. P. Galenko-Yaroshevskii
    A. S. Dukhanin
    V. A. Anisimova
    Bulletin of Experimental Biology and Medicine, 2003, 136 : 53 - 55
  • [2] Effects of clonidine and the association of clonidine with local anesthetics in peripheral nerve of rat
    Valinetti, EA
    Simonetti, MPB
    ANESTHESIOLOGY, 2000, 93 (3A) : U196 - U196
  • [3] Mechanisms underlying changes in indomethacin solubility with local anesthetics and related basic additives
    Shimada, Yohsuke
    Tateuchi, Ryo
    Chatani, Hitoshi
    Goto, Satoru
    JOURNAL OF MOLECULAR STRUCTURE, 2018, 1155 : 165 - 170
  • [4] COMBINED APPLICATION OF PROPRANOLOL AND LOCAL-ANESTHETICS - ENHANCED ANTICONVULSANT ACTION
    MULLER, M
    SCHRAMEK, J
    BIOMEDICA BIOCHIMICA ACTA, 1989, 48 (04) : 333 - 336
  • [5] MECHANISMS OF ACTION OF INHALATIONAL ANESTHETICS
    GLAUBER, HS
    SOUTH AFRICAN JOURNAL OF MEDICAL SCIENCES, 1976, 41 (04): : 305 - 326
  • [6] Mechanisms of action of general anesthetics
    Diao, Shu
    Ni, Jing
    Shi, Xiaowei
    Liu, Peirong
    Xia, Wei
    FRONTIERS IN BIOSCIENCE-LANDMARK, 2014, 19 : 747 - 757
  • [7] Mechanisms of action of general anesthetics
    Laudenbach, V.
    Inserm, Equipe Avenir
    ARCHIVES DE PEDIATRIE, 2006, 13 (06): : 775 - 777
  • [8] ON MODE OF ACTION OF LOCAL ANESTHETICS
    RITCHIE, JM
    GREENGARD, P
    ANNUAL REVIEW OF PHARMACOLOGY, 1966, 6 : 405 - +
  • [9] PHARMACOLOGICAL ACTION LOCAL ANESTHETICS
    ASTROM, A
    ACTA ANAESTHESIOLOGICA SCANDINAVICA, 1966, S : 19 - &
  • [10] BARBITURATES COMBINED WITH LOCAL ANESTHETICS
    ADRIANI, J
    ANESTHESIOLOGY, 1968, 29 (03) : 405 - &
12345