Activation and Regulation of Cytoplasmic Dynein

被引：49

作者：

Canty, John T. ^{[1
]}

Yildiz, Ahmet ^{[1
,2
,3
]}

机构：

[1] Univ Calif Berkeley, Biophys Grad Grp, Berkeley, CA 94720 USA

[2] Univ Calif Berkeley, Dept Mol & Cellular Biol, Berkeley, CA 94720 USA

[3] Univ Calif Berkeley, Phys Dept, Berkeley, CA 94720 USA

来源：

TRENDS IN BIOCHEMICAL SCIENCES | 2020年 / 45卷 / 05期

基金：

美国国家卫生研究院;

关键词：

TUG-OF-WAR; HUNTINGTIN-ASSOCIATED PROTEIN-1; AAA PLUS RING; DYNACTIN COMPLEX; LIGHT-CHAIN; IN-VIVO; CORTICAL DEVELOPMENT; CAUSE MALFORMATIONS; LISSENCEPHALY GENE; CRYSTAL-STRUCTURE;

D O I：

10.1016/j.tibs.2020.02.002

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Cytoplasmic dynein is an AAA(+) motor that drives the transport of many intracellular cargoes towards the minus end of microtubules (MTs). Previous in vitro studies characterized isolated dynein as an exceptionally weak motor that moves slowly and diffuses on an MT. Recent studies altered this view by demonstrating that dynein remains in an autoinhibited conformation on its own, and processive motility is activated when it forms a ternary complex with dynactin and a cargo adaptor. This complex assembles more efficiently in the presence of Lis1, providing an explanation for why Lis1 is a required cofactor for most cytoplasmic dynein-driven processes in cells. This review describes how dynein motility is activated and regulated by cargo adaptors and accessory proteins.

引用

页码：440 / 453

页数：14

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