Total Syntheses of Murrayamine E, I, and K

被引：63

作者：

Schuster, Christian ^{[1
]}

Julich-Gruner, Konstanze K. ^{[1
]}

Schnitzler, Heinrich ^{[1
]}

Hesse, Ronny ^{[1
]}

Jaeger, Anne ^{[1
]}

Schmidt, Arndt W. ^{[1
]}

Knoelker, Hans-Joachim ^{[1
]}

机构：

[1] Tech Univ Dresden, Dept Chem, D-01069 Dresden, Germany

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2015年 / 80卷 / 11期

关键词：

CARBAZOLE ALKALOIDS; BIOLOGICAL-ACTIVITY; RING-CLOSURE; KOENIGII; ETHERS; CONSTITUENTS; LEAVES;

D O I：

10.1021/acs.joc.5b00630

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

We describe efficient synthetic routes to murrayamine A (mukoenine C), O-methylmurrayamine A, mahanine, O-methylmahanine, and murrayamine D and the first total syntheses of murrayamine E, I, and R.. Key steps are a palladium-catalyzed construction of the carbazole framework and an: annulation of the pyran ring, which is either catalyzed by phenylboronic acid or promoted by a Lewis acid.

引用

页码：5666 / 5673

页数：8

共 55 条

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