New therapeutic strategies for the treatment of patent ductus arteriosus

被引：1
|
作者：
Dani, Carlo [1 ]
机构：
[1] Careggi Univ Hosp Florence, Sect Neonatol, Dept Med & Surg Crit Care, Florence, Italy
来源：
JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE | 2011年 / 24卷
关键词：
ductus arteriosus; ibuprofen; preterm infant; PRETERM INFANTS; PREMATURE-INFANTS; CONTROLLED-TRIAL; IBUPROFEN; INDOMETHACIN;
D O I：
10.3109/14767058.2011.607579
中图分类号：
R71 [妇产科学];
学科分类号：
100211 ;
摘要：
In the present manuscript we will focus our attention on the drug choice and its dosage. some studies suggest that the failure of pharmacologic pda closure might be due to the inadequacy of the standard dose regimen, because of large interindividual pharmacokinetics and pharmacodynamic variations in premature infants. we discuss the possibility that the early treatment of pda with ibuprofen doses higher than those actually recommended might increase the closure rate in preterm infants.
引用
收藏
页码：32 / 33
页数：2
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