Human chorionic gonadotropin as a target for cancer vaccines (Review)

被引：0

作者：

Triozzi, PL ^{[1
]}

Stevens, VC ^{[1
]}

机构：

[1] Ohio State Univ, Ctr Comprehens Canc, Arthur G James Canc Hosp & Res Inst, Columbus, OH 43210 USA

来源：

ONCOLOGY REPORTS | 1999年 / 6卷 / 01期

关键词：

human chorionic gonadotropin; cancer vaccines;

D O I：

暂无

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Human chorionic gonadotropin (hCG) is expressed by common cancers and may play a role in cell transformation as well as angiogenic, metastatic, and immune escape phenomena that are central to cancer progression. Clinical trials with a vaccine targeting the carboxy-terminal peptide of beta-hCG have indicated that tolerance to this oncofetal antigen can be broken. Humoral responses that may modulate the biologic activity of tumor-associated hCG as well as cellular responses to hCG have been generated. Studies are in progress to further define the biologic significance of hCG in cancer and to develop a vaccine approach that will best target this expression.

引用

页码：7 / 17

页数：11