Astrocyte-mediated potentiation of inhibitory synaptic transmission

被引：651

作者：

Kang, J

Jiang, L

Goldman, SA

Nedergaard, M

机构：

[1] New York Med Coll, Dept Cell Biol & Anat, Valhalla, NY 10595 USA

[2] Cornell Univ, Coll Med, Dept Neurol & Neurosci, New York, NY 10021 USA

来源：

NATURE NEUROSCIENCE | 1998年 / 1卷 / 08期

关键词：

D O I：

10.1038/3684

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

We investigated the role of astrocytes in activity-dependent modulation of inhibitory synaptic transmission in hippocampal slices. Repetitive firing of an interneuron decreased the probability of synaptic failures in spike-evoked inhibitory postsynaptic currents (unitary IPSCs) in CA1 pyramidal neurons. The GABA(B)-receptor antagonist CCP55845A abolished this effect. Direct stimulation of astrocytes, or application of the GABA(B)-receptor agonist baclofen, potentiated miniature inhibitory postsynaptic currents (mIPSCs) in pyramidal neurons. These effects were blocked by inhibition of astrocytic calcium signaling with the calcium chelator BAPTA or by antagonists of the ionotropic glutamate receptors. These observations suggest that interneuronal firing elicits a GABA(B)-receptor-mediated elevation of calcium in surrounding astrocytes, which in turn potentiates inhibitory transmission. Astrocytes may therefore be a necessary intermediary in activity-dependent modulation of inhibitory synapses in the hippocampus.

引用

页码：683 / 692

页数：10

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