Master Regulator Analysis of the SARS-CoV-2/Human Interactome

被引：135
|
作者：
Guzzi, Pietro H. [1 ]
Mercatelli, Daniele [2 ]
Ceraolo, Carmine [2 ]
Giorgi, Federico M. [2 ]
机构：
[1] Univ Catanzaro, Dept Surg & Med Sci, Catanzaro 88100, Italy
[2] Univ Bologna, Dept Pharm & Biotechnol, Bologna 40126, Italy
来源：
JOURNAL OF CLINICAL MEDICINE | 2020年 / 9卷 / 04期
关键词：
coronavirus; bioinformatics; gene network analysis; COVID-19; SARS-CoV-2; CONVERTING ENZYME 2; CASPASE-DEPENDENT APOPTOSIS; MULTIPLE SEQUENCE ALIGNMENT; E3 UBIQUITIN LIGASE; GENE-TRANSCRIPTION; VIRUS-REPLICATION; CORONAVIRUS; COMPLEX; PROTEIN; SARS;
D O I：
10.3390/jcm9040982
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
The recent epidemic outbreak of a novel human coronavirus called SARS-CoV-2 causing the respiratory tract disease COVID-19 has reached worldwide resonance and a global effort is being undertaken to characterize the molecular features and evolutionary origins of this virus. In this paper, we set out to shed light on the SARS-CoV-2/host receptor recognition, a crucial factor for successful virus infection. Based on the current knowledge of the interactome between SARS-CoV-2 and host cell proteins, we performed Master Regulator Analysis to detect which parts of the human interactome are most affected by the infection. We detected, amongst others, affected apoptotic and mitochondrial mechanisms, and a downregulation of the ACE2 protein receptor, notions that can be used to develop specific therapies against this new virus.
引用
收藏
页码：1 / 16
页数：15
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