Palladium(II)-Catalyzed Regioselective syn-Hydroarylation of Disubstituted Alkynes Using a Removable Directing Group

被引：98

作者：

Liu, Zhen ^{[1
]}

Derosa, Joseph ^{[1
]}

Engle, Keary M. ^{[1
]}

机构：

[1] Scripps Res Inst, Dept Chem, 10550 North Torrey Pines Rd, La Jolla, CA 92037 USA

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2016年 / 138卷 / 39期

关键词：

PALLADIUM-CATALYZED HYDROARYLATION; RH/M-TPPTC CATALYST; ARYLBORONIC ACIDS; ORGANOBORONIC ACIDS; BORONIC ACIDS; TRISUBSTITUTED ALKENES; RHODIUM; CYCLIZATION; YNAMIDES; SYSTEM;

D O I：

10.1021/jacs.6b08818

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A palladium(II)-catalyzed regioselective syn-hydroarylation reaction of homopropargyl amines has been developed, wherein-selectivity is controlled by a cleavable bidentate directing group: Under the optimized reaction conditions, both dialkyl and alkylaryl substrates were found to undergo hydroarylation with high selectivity. The products of this reaction contain a 4,4-disubstituted homoallylic amine motif that is commonly seen in drug molecules and other bioactive compounds.

引用

页码：13076 / 13081

页数：6

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