Emerging role of MyomiRs as biomarkers and therapeutic targets in skeletal muscle diseases

被引：10

作者：

Srivastava, Sukanya ^{[1
]}

Rathor, Richa ^{[1
]}

Singh, Som Nath ^{[1
]}

Suryakumar, Geetha ^{[1
]}

机构：

[1] Def Inst Physiol & Allied Sci DIPAS, Delhi, India

来源：

AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY | 2021年 / 321卷 / 05期

关键词：

MyomiR; nutrimiromics; skeletal muscle atrophy; therapeutics; SATELLITE CELLS; RESISTANCE EXERCISE; MICRORNA EXPRESSION; HYPOBARIC HYPOXIA; DENERVATED MUSCLE; PROTEIN-SYNTHESIS; DIFFERENTIATION; REGENERATION; ADAPTATIONS; ATROPHY;

D O I：

10.1152/ajpcell.00057.2021

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Several chronic diseases lead to skeletal muscle loss and a decline in physical performance. MicroRNAs (miRNAs) are small, noncoding RNAs, which have exhibited their role in the development and diseased state of the skeletal muscle. miRNA regulates gene expression by binding to the 30 untranslated region of its target mRNA. Due to the robust stability in biological fluids, miRNAs are ideal candidate as biomarker. These miRNAs provide a novel avenue in strengthening our awareness and knowledge about the factors governing skeletal muscle functions such as development, growth, metabolism, differentiation, and cell proliferation. It also helps in understanding the therapeutic strategies in improving or conserving skeletal muscle health. This review outlines the evidence regarding the present knowledge on the role miRNA as a potential biomarker in skeletal muscle diseases and their exploration might be a unique and potential therapeutic strategy for various skeletal muscle disorders.

引用

页码：C859 / C875

页数：17

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