Amino acids and peptides .44. Synthesis of stereoisomeric pentapeptides of thiol proteinase inhibitor

被引：0
|
作者：
Iguchi, S
Hirano, K
Okamoto, H
Okamoto, Y
Okada, Y
机构：
[1] KOBE GAKUIN UNIV, FAC PHARMACEUT SCI, NISHI KU, KOBE 65121, JAPAN
[2] DAIICHI COLL PHARMACEUT SCI, MINAMI KU, FUKUOKA 815, JAPAN
来源：
CHEMICAL & PHARMACEUTICAL BULLETIN | 1996年 / 44卷 / 08期
关键词：
thiol proteinase inhibitor; TPI common sequence; stereoisomeric pentapeptide; structure-activity relationship; circular dichroism spectra;
D O I：
暂无
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Stereoisomers of thiol proteinase inhibitor (TPI) were synthesized by a conventional solution method, Among them, iNoc-D-Gln-Val-Val-Ala-Ala-pNA weakly inhibited the amidolytic activity of papain, although iNoc-Gln-Val-Val-Ala-Ala-pNA inhibited papain activity fairly potently, However, the other five D-amino acid-containing peptides did not show any inhibitory effects on papain. The circular dichroism (CD) spectra of the enzyme-peptides mixtures were measured in order to study the relationship between the peptide anilides-papain interaction and the inhibitory activity.
引用
收藏
页码：1599 / 1602
页数：4
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