Serum peroxiredoxin-1 in patients undergoing carotid endarterectomy: A short report

被引：0

作者：

Ilzecki, Marek ^{[1
]}

Feldo, Marcin ^{[1
]}

Bogucka-Kocka, Anna ^{[2
]}

Zalewski, Daniel ^{[2
]}

Chmiel, Paulina ^{[2
]}

Dave, Shavn ^{[3
]}

Ilzecka, Joanna ^{[4
]}

机构：

[1] Med Univ Lublin, Chair & Dept Vasc Surg & Angiol, Staszica 11, PL-20081 Lublin, Poland

[2] Med Univ Lublin, Chair & Dept Biol & Genet, Lublin, Poland

[3] Univ Oklahoma, Hlth Sci Ctr Oklahoma City, Oklahoma City, OK USA

[4] Med Univ Lublin, Independent Neurol Rehabil Unit, Lublin, Poland

来源：

ACTA ANGIOLOGICA | 2021年 / 27卷 / 02期

关键词：

brain ischemia-reperfusion injury; carotid endarterectomy; peroxiredoxin-1; INFLAMMATION; CELLS;

D O I：

10.5603/AA.2021.0009

中图分类号：

R6 [外科学];

学科分类号：

1002 ; 100210 ;

摘要：

Introduction: Endarterectomy of the internal carotid artery (CEA) plays an important role in the prevention of cerebral ischemic stroke; however, this surgical procedure may cause neurological complications. The aim of this study was to evaluate changes in serum levels of the oxidative stress marker peroxiredoxin-1 (PRDX1) in patients undergoing CEA. Material and methods: Twenty-four patients undergoing endarterectomy for critical stenosis of the internal carotid artery participated in the study. Blood for testing was collected before CEA and twice after surgery. PRDX1 was determined by ELISA. Results: The timing of blood sampling did not affect PRDX1 levels (p > 0.05). There was no statistically significant difference in serum PRDX1 levels between male and female groups and depending on the age of the patients (p > 0.05). Conclusion: PRDX1 cannot be considered as a marker of neurological complications after CEA.

引用

页码：49 / 52

页数：4

共 17 条

[1] Proteomic analysis shows differential protein expression in endothelial progenitor cells between healthy subjects and ischemic stroke patients [J].

Brea, David ;

Rodriguez-Gonzalez, Raquel ;

Sobrino, Tomas ;

Rodriguez-Yanez, Manuel ;

Blanco, Miguel ;

Castillo, Jose .

NEUROLOGICAL RESEARCH, 2011, 33 (10) :1057-1063

[2]

Campbell BCV, 2020, LANCET, V396, P129, DOI 10.1016/S0140-6736(20)31179-X

[3] Ischaemic stroke [J].

Campbell, Bruce C., V ;

De Silva, Deidre A. ;

Macleod, Malcolm R. ;

Coutts, Shelagh B. ;

Schwamm, Lee H. ;

Davis, Stephen M. ;

Donnan, Geoffrey A. .

NATURE REVIEWS DISEASE PRIMERS, 2019, 5 (1)

[4] Peroxiredoxin sets the brain on fire after stroke [J].

Garcia-Bonilla, Lidia ;

Iadecola, Costantino .

NATURE MEDICINE, 2012, 18 (06) :858-859

[5] Peroxiredoxin 5 (PRX5) Is Correlated Inversely to Systemic Markers of Inflammation in Acute Stroke [J].

Kunze, Allison ;

Zierath, Dannielle ;

Tanzi, Patricia ;

Cain, Kevin ;

Becker, Kyra .

STROKE, 2014, 45 (02) :608-610

[6] Cerebral Hyperperfusion Syndrome After Carotid Intervention: A Review [J].

Lieb, Michael ;

Shah, Ujas ;

Hines, George L. .

CARDIOLOGY IN REVIEW, 2012, 20 (02) :84-89

[7] PRDX1 enhances cerebral ischemia-reperfusion injury through activation of TLR4-regulated inflammation and apoptosis [J].

Liu, Qiang ;

Zhang, Yuan .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2019, 519 (03) :453-461

[8] Carotid endarterectomy for symptomatic carotid stenosis [J].

Orrapin, Saritphat ;

Rerkasem, Kittipan .

COCHRANE DATABASE OF SYSTEMATIC REVIEWS, 2017, (06)

[9] Roles of peroxiredoxins in cancer, neurodegenerative diseases and inflammatory diseases [J].

Park, Mi Hee ;

Jo, Miran ;

Kim, Yu Ri ;

Lee, Chong-Kil ;

Hong, Jin Tae .

PHARMACOLOGY & THERAPEUTICS, 2016, 163 :1-23

[10] Predictive Factors of Silent Brain Infarcts after Asymptomatic Carotid Endarterectomy [J].

Pascot, Remy ;

Parat, Benjamin ;

Le Teurnier, Yann ;

Godet, Gilles ;

Gauvrit, Jean-Yves ;

Goueffic, Yann ;

Steinmetz, Eric ;

Cardon, Alain ;

Kaladji, Adrien .

ANNALS OF VASCULAR SURGERY, 2018, 51 :225-233

← 1 2 →