Competition for hydrogen-bond formation in the helix-coil transition and protein folding

被引:19
作者
Badasyan, A. V. [1 ]
Tonoyan, Sh. A. [2 ]
Mamasakhlisov, Y. Sh. [2 ]
Giacometti, Achille [1 ]
Benight, A. S. [3 ,4 ]
Morozov, V. F. [2 ]
机构
[1] Univ Ca Foscari Venezia, Dipartimento Sci Mol & Nanosistemi, I-30123 Venice, Italy
[2] Yerevan State Univ, Dept Mol Phys, Yerevan 375025, Armenia
[3] Portland State Univ, Dept Chem, Portland, OR 97207 USA
[4] Portland State Univ, Dept Phys, Portland, OR 97207 USA
来源
PHYSICAL REVIEW E | 2011年 / 83卷 / 05期
关键词
DNA DOUBLE HELIX; COLD DENATURATION; PHASE-DIAGRAMS; POTTS-MODEL; PRESSURE; THERMODYNAMICS; COOPERATIVITY; STACKING;
D O I
10.1103/PhysRevE.83.051903
中图分类号
O35 [流体力学]; O53 [等离子体物理学];
学科分类号
070204 ; 080103 ; 080704 ;
摘要
The problem of the helix-coil transition of biopolymers in explicit solvents, such as water, with the ability for hydrogen bonding with a solvent is addressed analytically using a suitably modified version of the Generalized Model of Polypeptide Chains. Besides the regular helix-coil transition, an additional coil-helix or reentrant transition is also found at lower temperatures. The reentrant transition arises due to competition between polymer-polymer and polymer-water hydrogen bonds. The balance between the two types of hydrogen bonding can be shifted to either direction through changes not only in temperature, but also by pressure, mechanical force, osmotic stress, or other external influences. Both polypeptides and polynucleotides are considered within a unified formalism. Our approach provides an explanation of the experimental difficulty of observing the reentrant transition with pressure and underscores the advantage of pulling experiments for studies of DNA. Results are discussed and compared with those reported in a number of recent publications with which a significant level of agreement is obtained.
引用
收藏
页数:9
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