Risk of sudden unexpected death in people with epilepsy and obstructive sleep apnea

This study aimed to determine whether severity of newly diagnosed obstructive sleep apnea (OSA) in people with epilepsy is associated with elevated sudden unexpected death in epilepsy (SUDEP) risk as calculated by the revised SUDEP-7 Inventory (rSUDEP-7). To this aim, a retrospective cross-sectional study was conducted at a single academic center. Adults >18 years of age with epilepsy and newly diagnosed OSA were retrospectively identified via electronic health records. Analysis was performed for subjects with confirmed epilepsy, OSA, and complete diagnostic PSG and rSUDEP-7 data. OSA severity was categorized as mild, moderate or severe. Logistic regression analysis was used to determine the association between OSA severity and rSUDEP-7 scores, adjusting for significantly different baseline characteristics. Of 86 subjects, OSA severity was classified as mild 38(44.2 %), moderate 25(29.1 %), and severe 23(26.7 %). Multivariate logistic regression demonstrated that severe OSA was significantly associated with rSUDEP-7 > 5 after adjusting for congestive heart failure and diabetes (OR:4.08,p = 0.046,CI:1.04-16.28), but was attenuated when male gender was added to the model (OR:3.91,p = 0.067, CI:0.91-16.77). In conclusion, severe OSA is associated with elevated SUDEP risk. As a treatable disorder, OSA may thus represent a modifiable SUDEP risk factor. However, future confirmatory studies involving the prospective, longitudinal evaluation of SUDEP from broader populations are required.