Experimental colonic carcinogenesis: A new animal model

被引：0
|
作者：
Meunier, B
Bardaxoglou, E
Lakehal, M
Chenal, C
Lancien, G
Campion, JP
Launois, B
机构：
[1] CTR HOSP, DEPT PATHOL, RENNES, FRANCE
[2] CTR ANTICANC, DEPT RADIAT THERAPY, RENNES, FRANCE
来源：
ANTICANCER RESEARCH | 1996年 / 16卷 / 4A期
关键词：
colonic carcinogenesis; N-methyl-N-nitrosourea;
D O I：
暂无
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
The aim of this work was to develop an animal model of accessible colonic tumors simulating human carcinogenesis. A segment of the colon was exteriorized to the skin in 60 rats and swabbed with N-methyl-N-nitrosourea. All the animals developed tumoral abnormalities or frank dysplasic tissue 7 months after the beginning of the experiment. This animal model which closely mimics human colonic carcinogenesis is particularly interesting because tumour development can be monitored in live animals without interrupting normal intestinal functions.
引用
收藏
页码：1863 / 1865
页数：3
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