Anthropometric and Pubertal Outcomes in Girls With Classical Congenital Adrenal Hyperplasia

被引:0
|
作者
Kaur, Japleen [1 ]
Singla, Mandeep [2 ]
Bhansali, Anil [2 ]
Bhadada, Sanjay [2 ]
Walia, Rama [2 ]
机构
[1] Postgrad Inst Med Educ & Res PGIMER, Dept Obstet & Gynecol, Chandigarh, India
[2] Postgrad Inst Med Educ & Res PGIMER, Dept Endocrinol, Chandigarh, India
关键词
Dexamethasone; Hydrocortisone; Prednisolone; 21 alpha-hydroxylase deficiency; Puberty; HEIGHT; ADULT; WOMEN;
D O I
暂无
中图分类号
R72 [儿科学];
学科分类号
100202 ;
摘要
Objective: To evaluate the anthropometric and pubertal outcomes, over a spectrum of treatment regimens and compliance. Methods: We reviewed records of the patients with classical CAH seen at the endocrinology clinic of a tertiary care center between 1995 and 2016. Results: 25 females were included in the study, the majority (80%) with simple virilizing variant. All patients had genital ambiguity since birth, yet 40% (10/25) presented much later with menstrual complaints. All patients received hydrocortisone, but some switched to dexamethasone (n=7) or prednisolone (n=4). 7/9 (77.9%) girls who achieved target height, were on hydrocortisone. Menarche occurred with corticosteroid treatment in 60% (15/25) patients at a median (IQR) age of 16 (12-22) years. Conclusion: Hydrocortisone seems to have a beneficial effect on linear growth. Once target height is achieved, dexamethasone may be considered as an alternative.
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页码:535 / 538
页数:4
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