Synthesis of dioxatricyclic segments of dictyoxetane.: Oxygenated 6,8-dimethyl-2,7-dioxatricyclo[4.2.1.03,8]nonanes show antitumor activity.

被引：21

作者：

Wittenberg, J

Beil, W

Hoffmann, HMR

机构：

[1] Univ Hannover, Inst Organ Chem, D-30167 Hannover, Germany

[2] Med Hsch Hannover, Inst Allgemeine Pharmakol, D-30625 Hannover, Germany

来源：

TETRAHEDRON LETTERS | 1998年 / 39卷 / 45期

关键词：

D O I：

10.1016/S0040-4039(98)01886-3

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Starting from 1,1-bisbenzyloxy propanone four oxetanes A, B, C and D representing the dioxatricyclic core of dictyoxetane were synthesized. All of them show a cytotoxic/cytostatic effect using a human gastric carcinoma and a human heptocellular cell line. The activity is comparable to that of 5-fluorouracil. (C) 1998 Elsevier Science Ltd. All rights reserved.

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页码：8259 / 8262

页数：4

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