Connected healthcare: Improving patient care using digital health technologies

被引：192
作者：
Awad, Atheer [1 ]
Trenfield, Sarah J. [1 ]
Pollard, Thomas D. [1 ]
Ong, Jun Jie [1 ]
Elbadawi, Moe [1 ]
McCoubrey, Laura E. [1 ]
Goyanes, Alvaro [1 ,2 ,3 ]
Gaisford, Simon [1 ,2 ]
Basit, Abdul W. [1 ,2 ]
机构：
[1] UCL, UCL Sch Pharm, 29-39 Brunswick Sq, London WC1N 1AX, England
[2] FabRx Ltd, Henwood House, Ashford TN24 8DH, Kent, England
[3] Univ Santiago de Compostela, Hlth Res Inst Santiago de Compostela IDIS, Dept Farmacol Farm & Tecnol Farmaceut I D Farma G, Fac Farm, Santiago De Compostela 15782, Spain
来源：
ADVANCED DRUG DELIVERY REVIEWS | 2021年 / 178卷
基金：
英国工程与自然科学研究理事会;
关键词：
Pharma industry 4; 0; Personalized medicines and drug delivery; Fourth industrial revolution; Additive manufacturing and 3D printing; Patient-centred smart health and medical; care; Artificial intelligence and machine learning; Wearable computing and electronics; Medical cyber-physical systems and; robotics; Digital pharmaceuticals and therapeutics; DRUG-DELIVERY; INGESTIBLE CAPSULE; CORE TEMPERATURE; WIRELESS CAPSULE; DOSAGE FORMS; REAL-TIME; 3D; SENSOR; BIOSENSORS; INTERNET;
D O I：
10.1016/j.addr.2021.113958
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Now more than ever, traditional healthcare models are being overhauled with digital technologies of Healthcare 4.0 increasingly adopted. Worldwide, digital devices are improving every stage of the patient care pathway. For one, sensors are being used to monitor patient metrics 24/7, permitting swift diagnosis and interventions. At the treatment stage, 3D printers are under investigation for the concept of person-alised medicine by allowing patients access to on-demand, customisable therapeutics. Robots are also being explored for treatment, by empowering precision surgery, rehabilitation, or targeted drug delivery. Within medical logistics, drones are being leveraged to deliver critical treatments to remote areas, collect samples, and even provide emergency aid. To enable seamless integration within healthcare, the Internet of Things technology is being exploited to form closed-loop systems that remotely communicate with one another. This review outlines the most promising healthcare technologies and devices, their strengths, drawbacks, and opportunities for clinical adoption. (c) 2021 Published by Elsevier B.V.
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收藏
页数：20
相关论文
共 268 条
[91]   Automated therapy preparation of isoleucine formulations using 3D printing for the treatment of MSUD: First single-centre, prospective, crossover study in patients [J].
Goyanes, Alvaro ;
Madla, Christine M. ;
Umerji, Aysha ;
Duran Pineiro, Goretti ;
Giraldez Montero, Jose Maria ;
Lamas Diaz, Maria Jesus ;
Gonzalez Barcia, Miguel ;
Taherali, Farhan ;
Sanchez-Pintos, Paula ;
Couce, Maria-Luz ;
Gaisford, Simon ;
Basit, Abdul W. .
INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2019, 567
[92]   Direct powder extrusion 3D printing: Fabrication of drug products using a novel single-step process [J].
Goyanes, Alvaro ;
Allahham, Nour ;
Trenfield, Sarah J. ;
Stoyanov, Edmont ;
Gaisford, Simon ;
Basit, Abdul W. .
INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2019, 567
[93]   PET/CT imaging of 3D printed devices in the gastrointestinal tract of rodents [J].
Goyanes, Alvaro ;
Fernandez-Ferreiro, Anxo ;
Majeed, Adil ;
Gomez-Lado, Noemi ;
Awad, Atheer ;
Luaces-Rodriguez, Andrea ;
Gaisford, Simon ;
Aguiar, Pablo ;
Basit, Abdul W. .
INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2018, 536 (01) :158-164
[94]   3D scanning and 3D printing as innovative technologies for fabricating personalized topical drug delivery systems [J].
Goyanes, Alvaro ;
Det-Amornrat, Usanee ;
Wang, Jie ;
Basit, Abdul W. ;
Gaisford, Simon .
JOURNAL OF CONTROLLED RELEASE, 2016, 234 :41-48
[95]   3D Printing of Medicines: Engineering Novel Oral Devices with Unique Design and Drug Release Characteristics [J].
Goyanes, Alvaro ;
Wang, Jie ;
Buanz, Asma ;
Martinez-Pacheco, Ramon ;
Telford, Richard ;
Gaisford, Simon ;
Basit, Abdul W. .
MOLECULAR PHARMACEUTICS, 2015, 12 (11) :4077-4084
[96]   The Sports Gene Inside the Science of Extraordinary Athletic Performance/What Makes the Perfect Athlete [J].
Greenbaum, Dov ;
Chen, Jieming ;
Gerstein, Mark .
SCIENCE, 2013, 342 (6158) :560-561
[97]   Development of novel 3D-printed robotic prosthetic for transradial amputees [J].
Gretsch, Kendall F. ;
Lather, Henry D. ;
Peddada, Kranti V. ;
Deeken, Corey R. ;
Wall, Lindley B. ;
Goldfarb, Charles A. .
PROSTHETICS AND ORTHOTICS INTERNATIONAL, 2016, 40 (03) :400-403
[98]   Selective Laser Sintering of Solid Oral Dosage Forms with Copovidone and Paracetamol Using a CO2 Laser [J].
Gueche, Yanis A. ;
Sanchez-Ballester, Noelia M. ;
Bataille, Bernard ;
Aubert, Adrien ;
Leclercq, Laurent ;
Rossi, Jean-Christophe ;
Soulairol, Ian .
PHARMACEUTICS, 2021, 13 (02)
[99]   Recent advances and future prospects in molecularly imprinted polymers-based electrochemical biosensors [J].
Gui, Rijun ;
Jin, Hui ;
Guo, Huijun ;
Wang, Zonghua .
BIOSENSORS & BIOELECTRONICS, 2018, 100 :56-70
[100]  
Gunasekeran DV, 2021, LANCET DIGIT HEALTH, V3, pe124, DOI 10.1016/S2589-7500(20)30287-9
567891011121314