Glucocorticoid/Adiponectin Axis Mediates Full Activation of Cold-Induced Beige Fat Thermogenesis

被引:3
作者
Luo, Liping [1 ]
Wang, Lu [1 ,2 ]
Luo, Yan [1 ,3 ,4 ]
Romero, Estevan [1 ]
Yang, Xin [1 ]
Liu, Meilian [1 ,5 ]
机构
[1] Univ New Mexico, Dept Biochem & Mol Biol, Hlth Sci Ctr, Albuquerque, NM 87131 USA
[2] Cent South Univ, Xiangya Hosp 2, Dept Psychiat, Changsha 410011, Peoples R China
[3] Cent South Univ, Xiangya Hosp 2, Dept Endocrinol & Metab, Metab Syndrome Res Ctr, Changsha 410011, Peoples R China
[4] Cent South Univ, Xiangya Hosp 2, Key Lab Diabet Immunol, Natl Clin Res Ctr Metab Dis, Changsha 410011, Peoples R China
[5] Univ New Mexico, Hlth Sci Ctr, Autophagy Inflammat & Metab Ctr, Albuquerque, NM 87131 USA
关键词
glucocorticoid; adiponectin; WAT; beige adipocytes; PPAR gamma; BROWN ADIPOSE-TISSUE; ENERGY-EXPENDITURE; INSULIN-RESISTANCE; GENE-EXPRESSION; INDUCED OBESITY; LIPID STORAGE; VISCERAL ADIPOSITY; RECEPTOR-GAMMA; PROTEIN-KINASE; TNF-ALPHA;
D O I
10.3390/biom11111573
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Glucocorticoids (GCs), a class of corticosteroids produced by the adrenal cortex in response to stress, exert obesity-promoting effects. Although adaptive thermogenesis has been considered an effective approach to counteract obesity, whether GCs play a role in regulating cold stress-induced thermogenesis remains incompletely understood. Here, we show that the circulating levels of stress hormone corticosterone (GC in rodents) were significantly elevated, whereas the levels of adiponectin, an adipokine that was linked to cold-induced adaptive thermogenesis, were decreased 48 h post cold exposure. The administration of a glucocorticoid hydrocortisone downregulated adiponectin protein and mRNA levels in both WAT and white adipocytes, and upregulated thermogenic gene expression in inguinal fat. In contrast, mifepristone, a glucocorticoid receptor antagonist, enhanced adiponectin expression and suppressed energy expenditure in vivo. Mechanistically, hydrocortisone suppressed adiponectin expression by antagonizing PPAR gamma in differentiated 3T3-L1 adipocytes. Ultimately, adiponectin deficiency restored mifepristone-decreased oxygen consumption and suppressed the expression of thermogenic genes in inguinal fat. Taken together, our study reveals that the GCs/adiponectin axis is a key regulator of beige fat thermogenesis in response to acute cold stress.
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页数:18
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