Dopamine D2/3 receptor availability in the striatum of antipsychotic-free older patients with schizophrenia-A [11C]-raclopride PET study

被引：10

作者：

Nakajima, Shinichiro ^{[1
,2
,3
,4
]}

Caravaggio, Fernando ^{[1
,5
]}

Mamo, David C. ^{[6
,7
]}

Mulsant, Benoit H. ^{[2
,3
,8
]}

Chung, Jun Ku ^{[1
,5
]}

Plitman, Eric ^{[1
,5
]}

Iwata, Yusuke ^{[1
,3
,4
]}

Gerretsen, Philip ^{[1
,2
,3
,5
]}

Uchida, Hiroyuki ^{[2
,4
]}

Suzuki, Takefumi ^{[4
]}

Mar, Wanna ^{[1
]}

Wilson, Alan A. ^{[1
,8
]}

Houle, Sylvain ^{[1
,8
]}

Graff-Guerrero, Ariel ^{[1
,2
,3
,8
]}

机构：

[1] Ctr Addict & Mental Hlth, Res Imaging Ctr, Toronto, ON M5T 1R8, Canada

[2] Ctr Addict & Mental Hlth, Geriatr Mental Hlth Div, Toronto, ON M5T 1R8, Canada

[3] Univ Toronto, Dept Psychiat, Toronto, ON, Canada

[4] Keio Univ, Sch Med, Dept Neuropsychiat, Tokyo, Japan

[5] Univ Toronto, Inst Med Sci, Toronto, ON, Canada

[6] Univ Malta, Dept Psychiat, Fac Med, Msida, Malta

[7] Univ Malta, Dept Psychiat, Fac Hlth Sci, Msida, Malta

[8] Ctr Addict & Mental Hlth, Campbell Res Inst, Toronto, ON M5T 1R8, Canada

来源：

SCHIZOPHRENIA RESEARCH | 2015年 / 164卷 / 1-3期

基金：

加拿大健康研究院; 美国国家卫生研究院;

关键词：

Schizophrenia; Aging; Dopamine; PET; D-2/3; receptor; POSITRON-EMISSION-TOMOGRAPHY; BINDING; BRAIN; ADULTS; SCALE;

D O I：

10.1016/j.schres.2015.02.020

中图分类号：

R749 [精神病学];

学科分类号：

100205 ;

摘要：

Background: No study has examined dopamine D-2/3 receptor (D2/3R) availability in antipsychotic-free older patients with schizophrenia. Methods: We included patients with schizophrenia 50 years or older who were antipsychotic-free for at least 3 months. We compared non-displaceable binding potential (BPND) of [C-11]-raclopride in the caudate, putamen, ventral striatum, and globus pallidus between patients and age-and sex-matched healthy controls. Results: Ten patients participated (antipsychotic-naive = 4). No differences in BPND were found between patients and controls in any ROIs (F(1, 72) = .42, p = .52). Conclusion: The preliminary results suggest no differences in D2/3R availability between antipsychotic-free older patients with schizophrenia and controls. (C) 2015 Elsevier B.V. All rights reserved.

引用

页码：263 / 267

页数：5

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