Dopamine D2/3 receptor availability in the striatum of antipsychotic-free older patients with schizophrenia-A [11C]-raclopride PET study

被引：10
作者：
Nakajima, Shinichiro [1 ,2 ,3 ,4 ]
Caravaggio, Fernando [1 ,5 ]
Mamo, David C. [6 ,7 ]
Mulsant, Benoit H. [2 ,3 ,8 ]
Chung, Jun Ku [1 ,5 ]
Plitman, Eric [1 ,5 ]
Iwata, Yusuke [1 ,3 ,4 ]
Gerretsen, Philip [1 ,2 ,3 ,5 ]
Uchida, Hiroyuki [2 ,4 ]
Suzuki, Takefumi [4 ]
Mar, Wanna [1 ]
Wilson, Alan A. [1 ,8 ]
Houle, Sylvain [1 ,8 ]
Graff-Guerrero, Ariel [1 ,2 ,3 ,8 ]
机构：
[1] Ctr Addict & Mental Hlth, Res Imaging Ctr, Toronto, ON M5T 1R8, Canada
[2] Ctr Addict & Mental Hlth, Geriatr Mental Hlth Div, Toronto, ON M5T 1R8, Canada
[3] Univ Toronto, Dept Psychiat, Toronto, ON, Canada
[4] Keio Univ, Sch Med, Dept Neuropsychiat, Tokyo, Japan
[5] Univ Toronto, Inst Med Sci, Toronto, ON, Canada
[6] Univ Malta, Dept Psychiat, Fac Med, Msida, Malta
[7] Univ Malta, Dept Psychiat, Fac Hlth Sci, Msida, Malta
[8] Ctr Addict & Mental Hlth, Campbell Res Inst, Toronto, ON M5T 1R8, Canada
来源：
SCHIZOPHRENIA RESEARCH | 2015年 / 164卷 / 1-3期
基金：
加拿大健康研究院; 美国国家卫生研究院;
关键词：
Schizophrenia; Aging; Dopamine; PET; D-2/3; receptor; POSITRON-EMISSION-TOMOGRAPHY; BINDING; BRAIN; ADULTS; SCALE;
D O I：
10.1016/j.schres.2015.02.020
中图分类号：
R749 [精神病学];
学科分类号：
100205 ;
摘要：
Background: No study has examined dopamine D-2/3 receptor (D2/3R) availability in antipsychotic-free older patients with schizophrenia. Methods: We included patients with schizophrenia 50 years or older who were antipsychotic-free for at least 3 months. We compared non-displaceable binding potential (BPND) of [C-11]-raclopride in the caudate, putamen, ventral striatum, and globus pallidus between patients and age-and sex-matched healthy controls. Results: Ten patients participated (antipsychotic-naive = 4). No differences in BPND were found between patients and controls in any ROIs (F(1, 72) = .42, p = .52). Conclusion: The preliminary results suggest no differences in D2/3R availability between antipsychotic-free older patients with schizophrenia and controls. (C) 2015 Elsevier B.V. All rights reserved.
引用
收藏
页码：263 / 267
页数：5
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