Potentiometric Determination of Fexofenadine Hydrochloride Drug by Fabrication of Liquid Membrane Electrodes

This paper presents a study in the electrochemical methods for the preparation of three new electrodes of Fexofenadine hydrochloride in a polymeric membrane. The first electrode was prepared from ion pair: molybdophosphoric acid reagent and fexofenadine cation with Di-n-butyl phthalate (DBPH), the subsequent electrode was prepared with O-Nitro phenyl octyl ether (NPOE) and the third electrode was set up by Tri-n-butyl phthalate (TBP), respectively as plasticizer for determination of Fexofenadine hydrochloride drug. Two electrodes indicated a Nernstian response with a slope of [57.01, 56.70] mV. decade(-1) for the first and for the second electrodes individually, with detection limits 5.6x10(-6) mole.L-1 for first electrode and 3.5x10(-6) mole.L-1 for the second electrode and the third electrode gave a non Nernstain response equivalent to 14.30 mV.decade(-1). The electrodes FEX-MPA-DBPH, FEX-MPA-NPOE, and FEX-MPA-TBP work adequately over the pH range (2.0-4.5), (2.5-4.0), and (2.0-4.0) for Fexofenadine hydrochloride electrodes, respectively. The impact of interfering species was insignificant as demonstrated by selectivity coefficient values. The viability of the electrodes FEX-MPA-DBPH, FEX-MPA-NPOE, and FEX-MPA-TBP proceeded in a timeframe (41,36, and 13) days, respectively. The recommended electrodes were successfully used for the determination of Fexofenadine hydrochloride in pure form and pharmaceuticals preparations. This work arrived at excellent outcomes as far as the linearity, and selectivity of the methods.