Determination of Benzocaine Using HPLC and FIA with Amperometric Detection on a Carbon Paste Electrode

被引：16
作者：
Dejmkova, Hana [1 ]
Vokalova, Veronika [1 ]
Zima, Jiri [1 ]
Barek, Jiri [1 ]
机构：
[1] Charles Univ Prague, Fac Sci, Dept Analyt Chem, UNESCO Lab Environm Electrochem, CZ-12843 Prague 2, Czech Republic
来源：
ELECTROANALYSIS | 2011年 / 23卷 / 03期
关键词：
Amperometric detection; Carbon paste electrode; FIA; HPLC; Pharmaceuticals; VOLTAMMETRIC DETERMINATION; LOCAL-ANESTHETICS; ELECTROANALYSIS;
D O I：
10.1002/elan.201000646
中图分类号：
O65 [分析化学];
学科分类号：
070302 ; 081704 ;
摘要：
A new method for benzocaine determination employing FIA and HPLC with electrochemical detection on a carbon paste electrode was developed. The optimum conditions for the determination were found. Carrier solution for FIA consisted of B-R buffer pH 4 (80% methanol, v/v) and used flow rate was 1.0 mLmin(-1). Mobile phase for HPLC consisted of B-R buffer pH 4 (75% methanol, v/v) with flow rate 0.4 mLmin(-1). Working potential of +1.2 V was employed. Practical applicability of the methods was tested on the determination of benzocaine in selected pharmaceuticals. The results were in agreement with results obtained using spectrophotometric detection and with one exception also with the content declared by the manufacturer.
引用
收藏
页码：662 / 666
页数：5
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