Enantioselective Total Synthesis of the Diterpenes Kempene-2, Kempene-1, and 3-epi-Kempene-1 from the Defense Secretion of Higher Termites

被引：34

作者：

Schubert, Melanie ^{[1
]}

Metz, Peter ^{[1
]}

机构：

[1] Tech Univ Dresden, Fachrichtung Chem & Lebensmittelchem Organ Chem 1, D-01069 Dresden, Germany

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2011年 / 50卷 / 13期

关键词：

asymmetric catalysis; cycloaddition; domino reactions; metathesis; natural products; CLOSING METATHESIS REACTIONS; KEMPANE DITERPENES; RING-SYSTEM; NASUTITERMITINAE; CONSTRUCTION; STRATEGY; DIENYNES;

D O I：

10.1002/anie.201007551

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

(Chemical Equation Presented) Two rings in one sweep: A domino metathesis of the bicyclic dienyne 4 (TBS=tertbutyldimethylsilyl) obtained from a catalytic enantioselective Diels-Alder reaction as the key process enabled the efficient preparation of the tetracyclic diterpenes kempene-2 (1), kempene-1 (2), and 3-epi-kempene-1 (3). © 2011 Wiley-VCH Verlag GmbH & Co. KGaA.

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页码：2954 / 2956

页数：3

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