Hospital Surveillance of Childhood Bacterial Meningitis in Senegal and the Introduction of Haemophilus influenzae Type b Conjugate Vaccine

被引：14

作者：

Ba, Osseynou ^{[6
]}

Fleming, Jessica A. ^{[5
]}

Dieye, Yakou ^{[6
]}

Mutombo, Boniface Mutombo Wa ^{[7
]}

Ba, Mamadou ^{[1
]}

Cisse, Moussa Fafa ^{[1
]}

Diallo, Aissatou Gaye ^{[8
]}

Sow, Iyane ^{[9
]}

Slack, Mary P. E. ^{[2
]}

Faye, Pape Coumba ^{[3
]}

Ba, Mady ^{[3
]}

Diallo, Ndiouga ^{[6
]}

Weiss, Noel S. ^{[4
]}

机构：

[1] Albert Royer Hosp, Dakar, Senegal

[2] Hlth Protect Agcy, Ctr Infect, WHO Collaborating Ctr Haemophilus Influenzae, Haemophilus Reference Unit,Resp & Syst Infect Lab, London, England

[3] Senegal Minist Hlth, Dakar, Senegal

[4] Univ Washington, Dept Epidemiol, Seattle, WA 98195 USA

[5] PATH Vaccine Access & Delivery, Seattle, WA 98121 USA

[6] PATH Senegal Project Off, Dakar, Senegal

[7] Chainama Hosp, Natl Malaria Control Ctr, Lusaka, Zambia

[8] LeDantec Hosp Lab, Dakar, Senegal

[9] Fann Hosp Lab, Dakar, Senegal

来源：

AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE | 2010年 / 83卷 / 06期

关键词：

REDUCES OROPHARYNGEAL CARRIAGE; DISEASE BURDEN; IMPACT; HIB; IMMUNIZATION; CHILDREN; PREVENTION;

D O I：

10.4269/ajtmh.2010.10-0346

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

Bacterial meningitis is an important cause of morbidity and mortality in children living in low-resource settings. Pediatric bacterial meningitis cases < 5 years of age were identified through a regional hospital surveillance system for 3 years after introduction of routine immunization with Haemophilus influenzae type b (Hib) conjugate vaccine in Senegal in July 2005. Cases from the national pediatric hospital were also tracked from 2002 to 2008. The regional surveillance system recorded 1,711 suspected pediatric bacterial meningitis cases. Of 214 laboratory-confirmed cases, 108 (50%) were caused by Streptococcus pneumoniae, 42 (20%) to Hib, and 13 (6%) to Neisseria meningitidis. There was a 98% reduction in the number of hospitalized Hib meningitis cases from Dakar Region in 2008 compared with 2002. The surveillance system provides important information to the Ministry of Health as they consider self-funding Hib vaccine and introducing pneumococcal vaccine.

引用

页码：1330 / 1335

页数：6

共 23 条

[1] Vaccination with a Haemophilus influenzae type b conjugate vaccine reduces oropharyngeal carriage of H-influenzae type b among Gambian children [J].