Sensitive determination of iron(III) by gold electrode modified with 2-mercaptosuccinic acid self-assembled monolayer

Preparation and application of gold 2-mercaptosuccinic acid self-assembled monolayer (Au-MSA SAM) electrode for determination of iron(III) in the presence of iron(II) is described by cyclic voltammetry, electrochemical impedance spectroscopy, and Osteryoung square wave voltammetry. The square wave voltammograms showed a sharp peak around positive potentials +0.250 V that was used for construction of the calibration curve. Parameters influencing the method were optimized. A linear range calibration curve from 1.0 x 10(-10) to 6.0 x 10(-9) M iron(III) with a detection limit of 3.0 x 10(-11) M and relative standard deviation (R.S.D.) of 6.5% for n = 8 at 1.0 x 10-9 M iron(III) was observed in the best conditions. Possible interferences from the coexisting ions were also investigated. The results demonstrated that sensor could be used for determination of iron(III) in the presence of various ions. The validity of the method and applicability of the sensor were successfully tested by determining of iron(III) in natural waters (tap and mineral waters) and in a pharmaceutical sample (Venofer (R) ampoule) without interference from sample matrix. The experimental data are presented and discussed from which the new sensor is characterized. (c) 2007 Elsevier B.V All rights reserved.