Convergence of Scaffold-Guided Bone Reconstruction and Surgical Vascularization Strategies-A Quest for Regenerative Matching Axial Vascularization

被引：23

作者：

Sparks, David S. ^{[1
,2
,3
]}

Savi, Flavia Medeiros ^{[1
]}

Saifzadeh, Siamak ^{[1
,4
]}

Schuetz, Michael A. ^{[5
,6
]}

Wagels, Michael ^{[2
,3
,7
]}

Hutmacher, Dietmar W. ^{[1
,8
]}

机构：

[1] Queensland Univ Technol, Ctr Regenerat Med, Inst Hlth & Biomed Innovat, Kelvin Grove, Qld, Australia

[2] Princess Alexandra Hosp, Dept Plast & Reconstruct Surg, Woolloongabba, Qld, Australia

[3] Univ Queensland, Sch Med, Southside Clin Div, Woolloongabba, Qld, Australia

[4] Queensland Univ Technol, Med Engn Res Facil, Chermside, Qld, Australia

[5] Royal Brisbane Hosp, Dept Orthopaed Surg, Herston, Qld, Australia

[6] Royal Brisbane Hosp, Jamieson Trauma Inst, Herston, Qld, Australia

[7] Australian Ctr Complex Integrated Surg Solut, Woolloongabba, Qld, Australia

[8] Queensland Univ Technol, ARC Ctr Addit Biomfg, Kelvin Grove, Qld, Australia

来源：

FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY | 2020年 / 7卷

基金：

澳大利亚研究理事会;

关键词：

tissue engineering; vascularization; bone; regeneration; blood vessel analysis; HUMAN OSTEOGENIC PROTEIN-1; ARTERIOVENOUS SHUNT LOOP; TISSUE-ENGINEERED BONE; DE-NOVO GENERATION; IN-VIVO BIOREACTOR; MANDIBULAR RECONSTRUCTION; STEM-CELLS; MORPHOGENETIC PROTEIN-2; FASCIOCUTANEOUS TISSUE; PERIOSTEAL FLAPS;

D O I：

10.3389/fbioe.2019.00448

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The prevalent challenge facing tissue engineering today is the lack of adequate vascularization to support the growth, function, and viability of tissue engineered constructs (TECs) that require blood vessel supply. The research and clinical community rely on the increasing knowledge of angiogenic and vasculogenic processes to stimulate a clinically-relevant vascular network formation within TECs. The regenerative matching axial vascularization approach presented in this manuscript incorporates the advantages of flap-based techniques for neo-vascularization yet also harnesses the in vivo bioreactor principle in a more directed "like for like" approach to further assist regeneration of the specific tissue type that is lost, such as a corticoperiosteal flap in critical sized bone defect reconstruction.

引用

页数：15