Effect of nonsteroidal anti-inflammatory drugs on lipid peroxidation by hydroxyl radical

被引：14
|
作者：
Tsujimoto, Y
Saitoh, K
Kashima, M
Shiozawa, A
Kozuka, M
Hashizume, H
Kimura, K
Yamazaki, M
Fujii, A
机构：
[1] Nihon Univ, Sch Dent Matsudo, Dept Endodont, Chiba 2718587, Japan
[2] Nihon Univ, Sch Dent Matsudo, Dept Pharmacol, Chiba 2718587, Japan
来源：
GENERAL PHARMACOLOGY | 1998年 / 31卷 / 03期
关键词：
NSAIDs; hydroxyl radical; lipid peroxidation; ESR; TBA;
D O I：
10.1016/S0306-3623(98)00044-5
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
1. Effects of acetaminophen and sodium salicylate on hydoxyl radical elimination were studied using an electron-spin-resonance spin-trapping method. The effects of these agents on lipid peroxidation of the human erythrocyte membrane were also investigated by the thiobarbituric acid method. 2. Acetaminophen and sodium salicylate depressed hydroxyl radical generated by Cu2+/H2O2. 3. Acetaminophen inhibited Cu2+/H2O2-dependent lipid peroxidation; however, sodium salicylate enhanced Cu2+/H2O2-dependent lipid peroxidation. GEN PHARMAC 31;3:405-408, 1998. (C) 1998 Elsevier Science Inc.
引用
收藏
页码：405 / 408
页数：4
相关论文
共 50 条
  • [21] Chirality and nonsteroidal anti-inflammatory drugs
    Hayball, PJ
    DRUGS, 1996, 52 : 47 - 58
  • [22] NEW NONSTEROIDAL ANTI-INFLAMMATORY DRUGS
    ZARRO, VJ
    AMERICAN FAMILY PHYSICIAN, 1976, 14 (03) : 142 - 144
  • [23] Nonsteroidal anti-inflammatory drugs for dysmenorrhoea
    Marjoribanks, Jane
    Ayeleke, Reuben Olugbenga
    Farquhar, Cindy
    Proctor, Michelle
    COCHRANE DATABASE OF SYSTEMATIC REVIEWS, 2015, (07):
  • [24] TUBERCULOSIS AND NONSTEROIDAL ANTI-INFLAMMATORY DRUGS
    TOMASSON, HO
    BRENNAN, M
    BASS, MJ
    CANADIAN MEDICAL ASSOCIATION JOURNAL, 1984, 130 (03) : 275 - 278
  • [25] ANEMIA AND NONSTEROIDAL ANTI-INFLAMMATORY DRUGS
    DOUBE, A
    BRITISH JOURNAL OF RHEUMATOLOGY, 1988, 27 (03): : 247 - 248
  • [26] Sensitivity to nonsteroidal anti-inflammatory drugs
    Namazy, JA
    Simon, RA
    ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY, 2002, 89 (06) : 542 - 550
  • [27] Nonsteroidal anti-inflammatory drugs and pharyngitis
    Mazzone, Stuart B.
    Kulasekaran, Anuradha
    Shea, Tim
    Adegoke, Oluwajoba
    IMMUNITY INFLAMMATION AND DISEASE, 2022, 10 (12)
  • [28] NEPHROTOXICITY OF NONSTEROIDAL ANTI-INFLAMMATORY DRUGS
    HAGLER, L
    AMERICAN FAMILY PHYSICIAN, 1984, 30 (05) : 27 - 29
  • [29] NEPHROTOXICITY OF NONSTEROIDAL ANTI-INFLAMMATORY DRUGS
    KHOKHAR, N
    AMERICAN FAMILY PHYSICIAN, 1984, 30 (01) : 123 - 128
  • [30] The nonsteroidal anti-inflammatory drugs controversy
    Yeomans, ND
    Garas, G
    Hawkey, CJ
    GASTROENTEROLOGY CLINICS OF NORTH AMERICA, 2000, 29 (04) : 791 - +
12345