FEMA GRAS assessment of natural flavor complexes: Origanum oil, thyme oil and related phenol derivative-containing flavoring ingredients

被引：15

作者：

Cohen, Samuel M. ^{[1
]}

Eisenbrand, Gerhard ^{[2
]}

Fukushima, Shoji ^{[3
]}

Gooderham, Nigel J. ^{[4
]}

Guengerich, F. Peter ^{[5
]}

Hecht, Stephen S. ^{[6
,7
]}

Rietjens, Ivonne M. C. M. ^{[8
]}

Rosol, Thomas J. ^{[9
]}

Davidsen, Jeanne M. ^{[10
]}

Harman, Christie L. ^{[10
]}

Lu, Vivian ^{[10
]}

Taylor, Sean, V ^{[11
]}

机构：

[1] Univ Nebraska Med Ctr, Dept Pathol & Microbiol, 983135 Nebraska Med Ctr, Omaha, NE 68198 USA

[2] Univ Kaiserslautern, Kuhler Grund 48-1, D-69126 Heidelberg, Germany

[3] Japan Bioassay Res Ctr, 2445 Hirasawa, Hadano, Kanagawa 2570015, Japan

[4] Imperial Coll London, Dept Metab Digest Reprod, Sir Alexander Fleming Bldg, London SW7 2AZ, England

[5] Vanderbilt Univ, Dept Biochem, Sch Med, Nashville, TN 37232 USA

[6] Masonic Canc Ctr, Canc & Cardiovasc Res Bldg,2231 6th St SE, Minneapolis, MN 55455 USA

[7] Dept Lab Med & Pathol, Canc & Cardiovasc Res Bldg,2231 6th St SE, Minneapolis, MN 55455 USA

[8] Wageningen Univ, Div Toxicol, Stippeneng 4, NL-6708 WE Wageningen, Netherlands

[9] Ohio Univ, Heritage Coll Osteopath Med, Dept Biomed Sci, 1 Ohio Univ, Athens, OH 45701 USA

[10] Flavor & Extract Manufacturers Assoc, 1101 17th St NW,Suite 700, Washington, DC 20036 USA

[11] FEMA Expert Panel, 1101 17th St NW,Suite 700, Washington, DC 20036 USA

来源：

FOOD AND CHEMICAL TOXICOLOGY | 2021年 / 155卷

关键词：

OXIDATIVE DNA-DAMAGE; ESSENTIAL PLANT OILS; SAFETY EVALUATION; CHROMOSOME-ABERRATIONS; TOXICOLOGICAL CONCERN; SUBSTANCES PRESENT; CARVACROL; MUTAGENICITY; TOXICITY; CELLS;

D O I：

10.1016/j.fct.2021.112378

中图分类号：

TS2 [食品工业];

学科分类号：

0832 ;

摘要：

In 2015, the Expert Panel of the Flavor and Extract Manufacturers Association (FEMA) initiated a re-evaluation of the safety of over 250 natural flavor complexes (NFCs) used as flavor ingredients, mostly consisting of a variety of essential oils and botanical extracts. This publication, seventh in the series, re evaluates NFCs with constituent profiles dominated by phenolic derivatives including carvacrol, thymol and related compounds using a constituent-based procedure first published in 2005 and updated in 2018. The procedure is based on the chemical characterization of each NFC as intended for commerce and the estimated intake of the constituent congeneric groups. The procedure applies the threshold of toxicological concern (TTC) concept and evaluates relevant data on absorption, metabolism, genotoxic potential and toxicology of the constituent congeneric groups and the NFC under evaluation. Herein, the FEMA Expert Panel affirmed the generally recognized as safe (GRAS) status of seven phenolic derivative based NFCs, Origanum Oil (Extractive) (FEMA 2828), Savory Summer Oil (FEMA 3013), Savory Summer Oleoresin (FEMA 3014), Savory Winter Oil (FEMA 3016), Savory Winter Oleoresin (FEMA 3017), Thyme Oil (FEMA 3064) and Thyme White Oil (FEMA 3065) under their conditions of intended use as flavor ingredients.

引用

页数：18

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