Glutamate receptors and learning and memory

被引:28
作者
Gecz, Jozef [1 ]
机构
[1] Womens & Childrens Hosp, SA Pathol, Dept Genet & Mol Pathol, Adelaide, SA, Australia
关键词
COGNITIVE IMPAIRMENT; GENETIC ENHANCEMENT; MICE; DISORDERS; MUTATIONS; SUBUNIT; GRIN2A;
D O I
10.1038/ng1110-925
中图分类号
Q3 [遗传学];
学科分类号
071007 ; 090102 ;
摘要
Glutamate receptors have long been implicated in neurological processes underpinning learning and memory. A new study now shows that mutations in genes encoding glutamate receptor subunits can cause variable neurodevelopmental phenotypes including intellectual disability and epilepsy.
引用
收藏
页码:925 / 926
页数:2
相关论文
共 15 条
  • [1] Mutations in GRIN2A and GRIN2B encoding regulatory subunits of NMDA receptors cause variable neurodevelopmental phenotypes
    Endele, Sabine
    Rosenberger, Georg
    Geider, Kirsten
    Popp, Bernt
    Tamer, Ceyhun
    Stefanova, Irina
    Milh, Mathieu
    Kortuem, Fanny
    Fritsch, Angela
    Pientka, Friederike K.
    Hellenbroich, Yorck
    Kalscheuer, Vera M.
    Kohlhase, Juergen
    Moog, Ute
    Rappold, Gudrun
    Rauch, Anita
    Ropers, Hans-Hilger
    von Spiczak, Sarah
    Toennies, Holger
    Villeneuve, Nathalie
    Villard, Laurent
    Zabel, Bernhard
    Zenker, Martin
    Laube, Bodo
    Reis, Andre
    Wieczorek, Dagmar
    Van Maldergem, Lionel
    Kutsche, Kerstin
    [J]. NATURE GENETICS, 2010, 42 (11) : 1021 - U153
  • [2] ARX:: a gene for all seasons
    Gecz, Jozef
    Cloosterman, Desiree
    Partington, Michael
    [J]. CURRENT OPINION IN GENETICS & DEVELOPMENT, 2006, 16 (03) : 308 - 316
  • [3] Impairment of suckling response, trigeminal neuronal pattern formation, and hippocampal LTD in NMDA receptor epsilon 2 subunit mutant mice
    Kutsuwada, T
    Sakimura, K
    Manabe, T
    Takayama, C
    Katakura, N
    Kushiya, E
    Natsume, R
    Watanabe, M
    Inoue, Y
    Yagi, T
    Aizawa, S
    Arakawa, M
    Takahashi, T
    Nakamura, Y
    Mori, H
    Mishina, M
    [J]. NEURON, 1996, 16 (02) : 333 - 344
  • [4] The role of neuronal complexes in human X-linked brain diseases
    Laumonnier, Frederic
    Cuthbert, Peter C.
    Grant, Seth G. N.
    [J]. AMERICAN JOURNAL OF HUMAN GENETICS, 2007, 80 (02) : 205 - 220
  • [5] Genotype to phenotype-discovery and characterization of novel genomic disorders in a "genotype-first" era
    Mefford, Heather C.
    [J]. GENETICS IN MEDICINE, 2009, 11 (12) : 836 - 842
  • [6] A defect in the ionotropic glutamate receptor 6 gene (GRIK2) is associated with autosomal recessive mental retardation
    Motazacker, Mohammad Mahdi
    Rost, Benjamin Rainer
    Hucho, Tim
    Garshasbi, Masoud
    Kahrizi, Kimia
    Ullmann, Reinhard
    Abedini, Seyedeh Sedigheh
    Nieh, Sahar Esmaeeli
    Amini, Saeid Hosseini
    Goswami, Chandan
    Tzschach, Andreas
    Jensen, Lars Riff
    Schmitz, Dietmar
    Ropers, Hans Hilger
    Najmabadi, Hossein
    Kuss, Andreas Walter
    [J]. AMERICAN JOURNAL OF HUMAN GENETICS, 2007, 81 (04) : 792 - 798
  • [7] Recurrent copy number changes in mentally retarded children harbour genes involved in cellular localization and the glutamate receptor complex
    Poot, Martin
    Eleveld, Marc J.
    van't Slot, Ruben
    van Amstel, Hans Kristian Ploos
    Hochstenbach, Ron
    [J]. EUROPEAN JOURNAL OF HUMAN GENETICS, 2010, 18 (01) : 39 - 46
  • [8] Deletions in 16p13 including GRIN2A in patients with intellectual disability, various dysmorphic features, and seizure disorders of the rolandic region
    Reutlinger, Constanze
    Helbig, Ingo
    Gawelczyk, Barbara
    Subero, Jose Ignacio Martin
    Toennies, Holger
    Muhle, Hiltrud
    Finsterwalder, Katrin
    Vermeer, Sascha
    Pfundt, Rolph
    Sperner, Juergen
    Stefanova, Irina
    Gillessen-Kaesbach, Gabriele
    von Spiczak, Sarah
    van Baalen, Andreas
    Boor, Rainer
    Siebert, Reiner
    Stephani, Ulrich
    Caliebe, Almuth
    [J]. EPILEPSIA, 2010, 51 (09) : 1870 - 1873
  • [9] Genetics of Early Onset Cognitive Impairment
    Ropers, Hans Hilger
    [J]. ANNUAL REVIEW OF GENOMICS AND HUMAN GENETICS, VOL 11, 2010, 11 : 161 - 187
  • [10] REDUCED HIPPOCAMPAL LTP AND SPATIAL-LEARNING IN MICE LACKING NMDA RECEPTOR EPSILON-1 SUBUNIT
    SAKIMURA, K
    KUTSUWADA, T
    ITO, I
    MANABE, T
    TAKAYAMA, C
    KUSHIYA, E
    YAGI, T
    AIZAWA, S
    INOUE, Y
    SUGIYAMA, H
    MISHINA, M
    [J]. NATURE, 1995, 373 (6510) : 151 - 155