Glutamate receptors and learning and memory

被引：29

作者：

Gecz, Jozef ^{[1
]}

机构：

[1] Womens & Childrens Hosp, SA Pathol, Dept Genet & Mol Pathol, Adelaide, SA, Australia

来源：

NATURE GENETICS | 2010年 / 42卷 / 11期

关键词：

COGNITIVE IMPAIRMENT; GENETIC ENHANCEMENT; MICE; DISORDERS; MUTATIONS; SUBUNIT; GRIN2A;

D O I：

10.1038/ng1110-925

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Glutamate receptors have long been implicated in neurological processes underpinning learning and memory. A new study now shows that mutations in genes encoding glutamate receptor subunits can cause variable neurodevelopmental phenotypes including intellectual disability and epilepsy.

引用

页码：925 / 926

页数：2

共 15 条

[1] Mutations in GRIN2A and GRIN2B encoding regulatory subunits of NMDA receptors cause variable neurodevelopmental phenotypes [J].

Endele, Sabine ;

Rosenberger, Georg ;

Geider, Kirsten ;

Popp, Bernt ;

Tamer, Ceyhun ;

Stefanova, Irina ;

Milh, Mathieu ;

Kortuem, Fanny ;

Fritsch, Angela ;

Pientka, Friederike K. ;

Hellenbroich, Yorck ;

Kalscheuer, Vera M. ;

Kohlhase, Juergen ;

Moog, Ute ;

Rappold, Gudrun ;

Rauch, Anita ;

Ropers, Hans-Hilger ;

von Spiczak, Sarah ;

Toennies, Holger ;

Villeneuve, Nathalie ;

Villard, Laurent ;

Zabel, Bernhard ;

Zenker, Martin ;

Laube, Bodo ;

Reis, Andre ;

Wieczorek, Dagmar ;

Van Maldergem, Lionel ;

Kutsche, Kerstin .

NATURE GENETICS, 2010, 42 (11) :1021-U153

[2] ARX:: a gene for all seasons [J].

Gecz, Jozef ;

Cloosterman, Desiree ;

Partington, Michael .

CURRENT OPINION IN GENETICS & DEVELOPMENT, 2006, 16 (03) :308-316

[3] Impairment of suckling response, trigeminal neuronal pattern formation, and hippocampal LTD in NMDA receptor epsilon 2 subunit mutant mice [J].

Kutsuwada, T ;

Sakimura, K ;

Manabe, T ;

Takayama, C ;

Katakura, N ;

Kushiya, E ;

Natsume, R ;

Watanabe, M ;

Inoue, Y ;

Yagi, T ;

Aizawa, S ;

Arakawa, M ;

Takahashi, T ;

Nakamura, Y ;

Mori, H ;

Mishina, M .

NEURON, 1996, 16 (02) :333-344

[4] The role of neuronal complexes in human X-linked brain diseases [J].

Laumonnier, Frederic ;

Cuthbert, Peter C. ;

Grant, Seth G. N. .

AMERICAN JOURNAL OF HUMAN GENETICS, 2007, 80 (02) :205-220

[5] Genotype to phenotype-discovery and characterization of novel genomic disorders in a "genotype-first" era [J].

Mefford, Heather C. .

GENETICS IN MEDICINE, 2009, 11 (12) :836-842

[6] A defect in the ionotropic glutamate receptor 6 gene (GRIK2) is associated with autosomal recessive mental retardation [J].

Motazacker, Mohammad Mahdi ;

Rost, Benjamin Rainer ;

Hucho, Tim ;

Garshasbi, Masoud ;

Kahrizi, Kimia ;

Ullmann, Reinhard ;

Abedini, Seyedeh Sedigheh ;

Nieh, Sahar Esmaeeli ;

Amini, Saeid Hosseini ;

Goswami, Chandan ;

Tzschach, Andreas ;

Jensen, Lars Riff ;

Schmitz, Dietmar ;

Ropers, Hans Hilger ;

Najmabadi, Hossein ;

Kuss, Andreas Walter .

AMERICAN JOURNAL OF HUMAN GENETICS, 2007, 81 (04) :792-798

[7] Recurrent copy number changes in mentally retarded children harbour genes involved in cellular localization and the glutamate receptor complex [J].

Poot, Martin ;

Eleveld, Marc J. ;

van't Slot, Ruben ;

van Amstel, Hans Kristian Ploos ;

Hochstenbach, Ron .

EUROPEAN JOURNAL OF HUMAN GENETICS, 2010, 18 (01) :39-46

[8] Deletions in 16p13 including GRIN2A in patients with intellectual disability, various dysmorphic features, and seizure disorders of the rolandic region [J].

Reutlinger, Constanze ;

Helbig, Ingo ;

Gawelczyk, Barbara ;

Subero, Jose Ignacio Martin ;

Toennies, Holger ;

Muhle, Hiltrud ;

Finsterwalder, Katrin ;

Vermeer, Sascha ;

Pfundt, Rolph ;

Sperner, Juergen ;

Stefanova, Irina ;

Gillessen-Kaesbach, Gabriele ;

von Spiczak, Sarah ;

van Baalen, Andreas ;

Boor, Rainer ;

Siebert, Reiner ;

Stephani, Ulrich ;

Caliebe, Almuth .

EPILEPSIA, 2010, 51 (09) :1870-1873

[9] Genetics of Early Onset Cognitive Impairment [J].

Ropers, Hans Hilger .

ANNUAL REVIEW OF GENOMICS AND HUMAN GENETICS, VOL 11, 2010, 11 :161-187

[10] REDUCED HIPPOCAMPAL LTP AND SPATIAL-LEARNING IN MICE LACKING NMDA RECEPTOR EPSILON-1 SUBUNIT [J].

SAKIMURA, K ;

KUTSUWADA, T ;

ITO, I ;

MANABE, T ;

TAKAYAMA, C ;

KUSHIYA, E ;

YAGI, T ;

AIZAWA, S ;

INOUE, Y ;

SUGIYAMA, H ;

MISHINA, M .

NATURE, 1995, 373 (6510) :151-155

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