Rapid decline in vaccine-boosted neutralizing antibodies against SARS-CoV-2 Omicron variant

被引：126

作者：

Lyke, Kirsten E. ^{[1
]}

Atmar, Robert L. ^{[2
]}

Islas, Clara Dominguez ^{[3
]}

Posavad, Christine M. ^{[3
,4
]}

Szydlo, Daniel ^{[5
]}

Chourdhury, Rahul Paul ^{[5
]}

Deming, Meagan E. ^{[1
]}

Eaton, Amanda ^{[6
]}

Jackson, Lisa A. ^{[7
]}

Branche, Angela R. ^{[8
]}

Sahly, Hana M. El ^{[2
]}

Rostad, Christina A. ^{[9
]}

Martin, Judith M. ^{[10
]}

Johnston, Christine ^{[3
,4
,11
]}

Rupp, Richard E. ^{[12
]}

Mulligan, Mark J. ^{[13
]}

Brady, Rebecca C. ^{[14
]}

Frenck, Robert W., Jr. ^{[14
]}

Backer, Martin ^{[15
]}

Kottkamp, Angelica C. ^{[13
]}

Babu, Tara M. ^{[11
]}

Rajakumar, Kumaravel ^{[10
]}

Edupuganti, Srilatha ^{[16
,17
]}

Dobrzynski, David ^{[8
]}

Coler, Rhea N. ^{[18
,19
]}

Archer, Janet I. ^{[20
]}

Crandon, Sonja ^{[21
]}

Zemanek, Jillian A. ^{[5
]}

Brown, Elizabeth R. ^{[3
]}

Neuzil, Kathleen M. ^{[1
]}

Stephens, David S. ^{[16
]}

Post, Diane J. ^{[21
]}

Nayak, Seema U. ^{[21
]}

Suthar, Mehul S. ^{[22
]}

Roberts, Paul C. ^{[21
]}

Beigel, John H. ^{[21
]}

Montefiori, David C. ^{[23
]}

DMID Std Grp

机构：

[1] Univ Maryland Sch Med, Ctr Vaccine Dev & Global Hlth, Baltimore, MD 21201 USA

[2] Baylor Coll Med, Dept Med & Mol Virol & Microbiol, Houston, TX 77030 USA

[3] Univ Washington, Fred Hutchinson Canc Res Ctr, Vaccine & Infect Dis Div, Seattle, WA USA

[4] Univ Washington, Fred Hutchinson Canc Res Ctr, Dept Lab Med & Pathol, Seattle, WA USA

[5] Univ Washington, Stat Ctr HIV AIDS Res & Prevent SCHARP, Fred Hutchinson Canc Res Ctr, Seattle, WA USA

[6] Duke Univ Med Ctr, Dept Surg, Durham, NC USA

[7] Kaiser Permanente Washington Hlth Res Inst, Seattle, WA USA

[8] Univ Rochester, Dept Med, Div Infect Dis, Rochester, NY USA

[9] Emory Univ Sch Med & Childrens Healthcare Atlanta, Ctr Childhood Infect & Vaccines, Dept Pediat, Atlanta, GA USA

[10] Univ Pittsburgh Sch Med, Dept Pediat, Pittsburgh, PA USA

[11] Univ Washington, Dept Med, Seattle, WA USA

[12] Univ Texas Med Branch, Sealy Inst Vaccine Sci, Galveston, TX USA

[13] NYU Langone Vaccine Ctr, NYU Grossman Sch Med, Dept Med, Div Infect Dis & Immunol, New York, NY USA

[14] Univ Cincinnati Coll Med, Cincinnati Childrens Hosp Med Ctr, Div Infect Dis, Cincinnati, OH USA

[15] NYU Langone Hosp, Mineola, NY USA

[16] Emory Univ Sch Med, Dept Med, Atlanta, GA USA

[17] Hope Clin Emory Vaccine Ctr, Atlanta, GA USA

[18] Univ Washington Sch Med, Seattle Childrens Res Inst, Seattle, WA USA

[19] Univ Washington Sch Med, Dept Pediat, Seattle, WA USA

[20] FHI360, Durham, NC 27701 USA

[21] Natl Inst Allergy & Infect Dis, NIH, Div Microbiol & Infect Dis, Bethesda, MD USA

[22] Emory Univ, Atlanta, GA USA

[23] Duke Univ Med Ctr, Duke Human Vaccine Inst, Durham, NC 27710 USA

来源：

CELL REPORTS MEDICINE | 2022年 / 3卷 / 07期

基金：

美国国家卫生研究院;

关键词：

BA.2.12.1; BA.4/BA.5; booster; COVID-19; mRNA vaccine; neutralizing antibody; Omicron variant; recombinant adenovirus vaccine; SARS-CoV-2; sublineage;

D O I：

10.1016/j.xcrm.2022.100679

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The Omicron variant of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) exhibits reduced susceptibility to vaccine-induced neutralizing antibodies, requiring a boost to generate protective immunity. We assess the magnitude and short-term durability of neutralizing antibodies after homologous and heterologous boosting with mRNA and Ad26.COV2.S vaccines. All prime-boost combinations substantially increase the neutralization titers to Omicron, although the boosted titers decline rapidly within 2 months from the peak response compared with boosted titers against the prototypic D614G variant. Boosted Omicron neutralization titers are substantially higher for homologous mRNA vaccine boosting, and for heterologous mRNA and Ad26.COV2.S vaccine boosting, compared with homologous Ad26.COV2.S boosting. Homologous mRNA vaccine boosting generates nearly equivalent neutralizing activity against Omicron sublineages BA.1, BA.2, and BA.3 but modestly reduced neutralizing activity against BA.2.12.1 and BA.4/BA.5 compared with BA.1. These results have implications for boosting requirements to protect against Omicron and future variants of SARS-CoV-2.

引用

页数：13

共 50 条

[41] Broadly neutralizing antibodies against Omicron-included SARS-CoV-2 variants induced by vaccination
Xiangyang Chi
Yingying Guo
Guanying Zhang
Hancong Sun
Jun Zhang
Min Li
Zhengshan Chen
Jin Han
Yuanyuan Zhang
Xinghai Zhang
Pengfei Fan
Zhe Zhang
Busen Wang
Xiaodong Zai
Xuelian Han
Meng Hao
Ting Fang
Jinghan Xu
Shipo Wu
Yi Chen
Yingying Fang
Yunzhu Dong
Bingjie Sun
Jinlong Zhang
Jianmin Li
Guangyu Zhao
Changming Yu
Qiang Zhou
Wei Chen
Signal Transduction and Targeted Therapy, 7
[42] Broadly neutralizing antibodies against Omicron-included SARS-CoV-2 variants induced by vaccination
Chi, Xiangyang
Guo, Yingying
Zhang, Guanying
Sun, Hancong
Zhang, Jun
Li, Min
Chen, Zhengshan
Han, Jin
Zhang, Yuanyuan
Zhang, Xinghai
Fan, Pengfei
Zhang, Zhe
Wang, Busen
Zai, Xiaodong
Han, Xuelian
Hao, Meng
Fang, Ting
Xu, Jinghan
Wu, Shipo
Chen, Yi
Fang, Yingying
Dong, Yunzhu
Sun, Bingjie
Zhang, Jinlong
Li, Jianmin
Zhao, Guangyu
Yu, Changming
Zhou, Qiang
Chen, Wei
SIGNAL TRANSDUCTION AND TARGETED THERAPY, 2022, 7 (01)
[43] Broadly neutralizing antibodies overcome SARS-CoV-2 Omicron antigenic shift
Cameroni, Elisabetta
Bowen, John E.
Rosen, Laura E.
Saliba, Christian
Zepeda, Samantha K.
Culap, Katja
Pinto, Dora
VanBlargan, Laura A.
De Marco, Anna
di Iulio, Julia
Zatta, Fabrizia
Kaiser, Hannah
Noack, Julia
Farhat, Nisar
Czudnochowski, Nadine
Havenar-Daughton, Colin
Sprouse, Kaitlin R.
Dillen, Josh R.
Powell, Abigail E.
Chen, Alex
Maher, Cyrus
Yin, Li
Sun, David
Soriaga, Leah
Bassi, Jessica
Silacci-Fregni, Chiara
Gustafsson, Claes
Franko, Nicholas M.
Logue, Jenni
Iqbal, Najeeha Talat
Mazzitelli, Ignacio
Geffner, Jorge
Grifantini, Renata
Chu, Helen
Gori, Andrea
Riva, Agostino
Giannini, Olivier
Ceschi, Alessandro
Ferrari, Paolo
Cippa, Pietro E.
Franzetti-Pellanda, Alessandra
Garzoni, Christian
Halfmann, Peter J.
Kawaoka, Yoshihiro
Hebner, Christy
Purcell, Lisa A.
Piccoli, Luca
Pizzuto, Matteo Samuele
Walls, Alexandra C.
Diamond, Michael S.
NATURE, 2022, 602 (7898) : 664 - +
[44] mRNA-based COVID-19 vaccine boosters induce neutralizing immunity against SARS-CoV-2 Omicron variant
Garcia-Beltran, Wilfredo F.
St Denis, Kerri J.
Hoelzemer, Angelique
Lam, Evan C.
Nitido, Adam D.
Sheehan, Maegan L.
Berrios, Cristhian
Ofoman, Onosereme
Chang, Christina C.
Hauser, Blake M.
Feldman, Jared
Roederer, Alex L.
Gregory, David J.
Poznansky, Mark C.
Schmidt, Aaron G.
Iafrate, A. John
Naranbhai, Vivek
Balazs, Alejandro B.
CELL, 2022, 185 (03) : 457 - +
[45] Broadly neutralizing antibodies against SARS-CoV-2 variants
Linqi Zhang
NationalScienceOpen, 2022, 1 (01) : 24 - 31
[46] SARS-CoV-2 vaccine-induced antibodies protect against Omicron breakthrough infection
Baerends, Eva A. M.
Hvidt, Astrid K.
Reekie, Joanne
Sogaard, Ole S.
Staerke, Nina B.
Raben, Dorthe
Nielsen, Henrik
Petersen, Kristine T.
Juhl, Maria R.
Johansen, Isik S.
Lindvig, Susan O.
Madsen, Lone W.
Wiese, Lothar
Knudsen, Lene S.
Iversen, Mette B.
Benfield, Thomas
Iversen, Kasper K.
Andersen, Sidsel D.
Juhl, Anna K.
Dietz, Lisa L.
Andreasen, Signe R.
Fischer, Thea K.
Erikstrup, Christian
Valentiner-Branth, Palle
Lundgren, Jens
Ostergaard, Lars
Tolstrup, Martin
ISCIENCE, 2023, 26 (09)
[47] Airborne Transmission of the SARS-CoV-2 Delta Variant and the SARS-CoV-2 Omicron Variant
Lee, Byung Uk
AEROSOL AND AIR QUALITY RESEARCH, 2022, 22 (01)
[48] Increased resistance of SARS-CoV-2 Omicron variant to neutralization by vaccine-elicited and therapeutic antibodies
Tada, Takuya
Zhou, Hao
Dcosta, Belinda M.
Samanovic, Marie I.
Chivukula, Vidya
Herati, Ramin S.
Hubbard, Stevan R.
Mulligan, Mark J.
Landau, Nathaniel R.
EBIOMEDICINE, 2022, 78
[49] Deep learning-based rapid generation of broadly reactive antibodies against SARS-CoV-2 and its Omicron variant
Lou, Hantao
Zheng, Jianqing
Fang, Xiaohang
Liang, Zhu
Zhang, Meihan
Chen, Yu
Wang, Chunmei
Cao, Xuetao
CELL RESEARCH, 2023, 33 (01) : 80 - 82
[50] Deep learning-based rapid generation of broadly reactive antibodies against SARS-CoV-2 and its Omicron variant
Hantao Lou
Jianqing Zheng
Xiaohang (Leo) Fang
Zhu Liang
Meihan Zhang
Yu Chen
Chunmei Wang
Xuetao Cao
Cell Research, 2023, 33 : 80 - 82

← 1 2 3 4 5 →