One new nucleoside and three furanpentanone derivatives from the aerial part of Rubia cordifolia L

被引：3

作者：

He, Dong-Bing ^{[1
]}

Bai, Xue ^{[3
]}

Ma, Yu-Han ^{[1
]}

Qin, Hai-Jun ^{[1
]}

Wu, Yi-Bing ^{[1
]}

Lv, Dong-Jin ^{[4
]}

Mei, Ren-Qiang ^{[2
]}

机构：

[1] Hefei China Resources Shenlu Pharmaceut Co, Hefei 230601, Anhui, Peoples R China

[2] Kunming Inst Bot, Chinese Acad Sci, Resources West China, Kunming 650201, Yunnan, Peoples R China

[3] Chinese Acad Sci, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China

[4] Kunming Med Univ, Affiliated Hosp 3, Dept Med Oncol, Kunming 650118, Yunnan, Peoples R China

来源：

PHYTOCHEMISTRY LETTERS | 2021年 / 41卷

关键词：

Rubia cordifolia; Secondary metabolites; NO production inhibition; A-C; ROOTS; ANTHRAQUINONES; CYTOTOXICITY; CONSTITUENTS;

D O I：

10.1016/j.phytol.2020.11.009

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

One new nucleoside 1 and three new furanpentone derivatives 2-4 were isolated from the aerial part of Rubia cordifolia. Their structures were established using spectroscopic methods. Compounds 1 and 4 exhibited inhibition of NO production with IC50 values of 27.5 and 19.8 mu M, respectively.

引用

页码：125 / 128

页数：4

共 27 条

[1] RUBIATRIOL, A NEW TRITERPENOID FROM THE CHINESE DRUG, QIAN-CAO-GEN, RUBIA-CORDIFOLIA [J].

ARISAWA, M ;

UENO, H ;

NIMURA, M ;

HAYASHI, T ;

MORITA, N .

JOURNAL OF NATURAL PRODUCTS, 1986, 49 (06) :1114-1116

[2] Rubiasins A-C, new anthracene derivatives from the roots and stems of Rubia cordifolia [J].

Chang, LC ;

Chávez, D ;

Gills, JJ ;

Fong, HHS ;

Pezzuto, JM ;

Kinghorn, AD .

TETRAHEDRON LETTERS, 2000, 41 (37) :7157-7162

[3] Rubicordins A-C, new cyclopeptides from Rubia cordifolia with cytotoxicity and inhibiting NF-κB signaling pathway [J].

Chen, Xiao-Qiang ;

Zhao, Si-Meng ;

Wang, Zhe ;

Zeng, Guang-Zhi ;

Huang, Mao-Bo ;

Tan, Ning-Hua .

TETRAHEDRON, 2015, 71 (52) :9673-9678

[4] Anti-diarrheal and anti-inflammatory activities of aqueous extract of the aerial part of Rubia cordifolia [J].

Gong, Xue-Peng ;

Sun, Yuan-Yuan ;

Chen, Wei ;

Guo, Xia ;

Guan, Jian-Kun ;

Li, Dong-Yan ;

Du, Guang .

BMC COMPLEMENTARY AND ALTERNATIVE MEDICINE, 2017, 17

[5] Production of monoclonal antibodies against antitumor cyclohexapeptide RA-VII from Rubia cordifolia and their characterization [J].

Hasuda, Tomoyo ;

Hitotsuyanagi, Yukio ;

Takeya, Koichi .

JOURNAL OF NATURAL MEDICINES, 2011, 65 (3-4) :588-593

[6] O-Seco-RA-XXIV, a possible precursor of an antitumor peptide RA-XXIV, from Rubia cordifolia L. [J].

Hitotsuyanagi, Yukio ;

Kusano, Jun-ichi ;

Kim, Ik-Hwi ;

Hasuda, Tomoyo ;

Fukaya, Haruhiko ;

Takeya, Koichi .

PHYTOCHEMISTRY LETTERS, 2012, 5 (02) :335-339

[7] Isolation, Structure Determination, and Synthesis of Allo-RA-V and Neo-RA-V, RA-Series Bicyclic Peptides from Rubia cordifolia L. [J].

Hitotsuyanagi, Yukio ;

Odagiri, Masumi ;

Kato, Saori ;

Kusano, Jun-ichi ;

Hasuda, Tomoyo ;

Fukaya, Haruhiko ;

Takeya, Koichi .

CHEMISTRY-A EUROPEAN JOURNAL, 2012, 18 (10) :2839-2846

[8]

Ibraeim Z.Z., 2009, B FAC PHARM CAIRO U, V47, P233

[9]

ITOKAWA H, 1993, CHEM PHARM BULL, V41, P1869, DOI 10.1248/cpb.41.1869

[10] Constituents with DNA Topoisomerases I and II Inhibitory Activity and Cytotoxicity from the Roots of Rubio cordifolia [J].

Jeong, Su-Yang ;

Zhao, Bing-Tian ;

Lee, Chong-Soon ;

Son, Jong-Keun ;

Min, Byung-Sun ;

Woo, Mi-Hee .

PLANTA MEDICA, 2012, 78 (02) :177-181

← 1 2 3 →