Viruses and Type 1 Diabetes: From Enteroviruses to the Virome

被引：30
|
作者：
Isaacs, Sonia R. [1 ,2 ]
Foskett, Dylan B. [1 ,2 ]
Maxwell, Anna J. [1 ,2 ]
Ward, Emily J. [1 ,3 ]
Faulkner, Clare L. [1 ,2 ]
Luo, Jessica Y. X. [1 ,2 ]
Rawlinson, William D. [1 ,2 ,3 ,4 ]
Craig, Maria E. [1 ,2 ,5 ,6 ]
Kim, Ki Wook [1 ,2 ]
机构：
[1] Univ New South Wales, Fac Med & Hlth, Sch Womens & Childrens Hlth, Sydney, NSW 2031, Australia
[2] Prince Wales Hosp, Serol & Virol Div, Virol Res Lab, NSW Hlth Pathol, Sydney, NSW 2031, Australia
[3] Univ New South Wales, Fac Med & Hlth, Sch Med Sci, Sydney, NSW 2052, Australia
[4] Univ New South Wales, Fac Sci, Sch Biotechnol & Biomol Sci, Sydney, NSW 2052, Australia
[5] Childrens Hosp Westmead, Inst Endocrinol & Diabet, Sydney, NSW 2145, Australia
[6] Univ Sydney, Fac Med & Hlth, Discipline Child & Adolescent Hlth, Sydney, NSW 2006, Australia
来源：
MICROORGANISMS | 2021年 / 9卷 / 07期
基金：
英国医学研究理事会;
关键词：
enterovirus; type; 1; diabetes; virome; vaccine; antiviral; islet autoimmunity; coxsackievirus; next-generation sequencing; unbiased sequencing; HUMAN GUT VIROME; INCREASED INTESTINAL PERMEABILITY; AMINO-ACID SUBSTITUTION; INDUCED GENE-EXPRESSION; BETA-CELL AUTOIMMUNITY; CAPSID PROTEIN VP1; ISLET AUTOIMMUNITY; COXSACKIEVIRUS B3; EARLY-LIFE; RESPIRATORY-INFECTIONS;
D O I：
10.3390/microorganisms9071519
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
For over a century, viruses have left a long trail of evidence implicating them as frequent suspects in the development of type 1 diabetes. Through vigorous interrogation of viral infections in individuals with islet autoimmunity and type 1 diabetes using serological and molecular virus detection methods, as well as mechanistic studies of virus-infected human pancreatic beta-cells, the prime suspects have been narrowed down to predominantly human enteroviruses. Here, we provide a comprehensive overview of evidence supporting the hypothesised role of enteroviruses in the development of islet autoimmunity and type 1 diabetes. We also discuss concerns over the historical focus and investigation bias toward enteroviruses and summarise current unbiased efforts aimed at characterising the complete population of viruses (the "virome") contributing early in life to the development of islet autoimmunity and type 1 diabetes. Finally, we review the range of vaccine and antiviral drug candidates currently being evaluated in clinical trials for the prevention and potential treatment of type 1 diabetes.
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页数：26
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