Perfecting and extending the near-infrared imaging window

被引:213
作者
Feng, Zhe [1 ,2 ]
Tang, Tao [3 ]
Wu, Tianxiang [1 ]
Yu, Xiaoming [4 ]
Zhang, Yuhuang [1 ,2 ]
Wang, Meng [3 ]
Zheng, Junyan [4 ]
Ying, Yanyun [4 ]
Chen, Siyi [1 ]
Zhou, Jing [1 ]
Fan, Xiaoxiao [4 ]
Li, Shengliang [5 ]
Zhang, Mingxi [3 ]
Qian, Jun [1 ,2 ]
机构
[1] Zhejiang Univ, Int Res Ctr Adv Photon, Coll Opt Sci & Engn, Ctr Opt & Electromagnet Res,State Key Lab Modern, Hangzhou 310058, Peoples R China
[2] Zhejiang Univ, Jiaxing Inst, Intelligent Opt & Photon Res Ctr, Jiaxing 314000, Zhejiang, Peoples R China
[3] Wuhan Univ Technol, State Key Lab Adv Technol Mat Synth & Proc, Wuhan 430070, Peoples R China
[4] Zhejiang Univ, Sch Med, Womens Hosp, Dept Reprod Endocrinol,Key Lab Reprod Genet,Minis, Hangzhou 310006, Peoples R China
[5] Soochow Univ, Coll Pharmaceut Sci, Suzhou 215123, Peoples R China
基金
中国国家自然科学基金;
关键词
PHOTOTHERMAL THERAPY; FLUORESCENCE; EMISSION; DOTS; TISSUE; WATER;
D O I
10.1038/s41377-021-00628-0
中图分类号
O43 [光学];
学科分类号
070207 ; 0803 ;
摘要
In vivo fluorescence imaging in the second near-infrared window (NIR-II) has been considered as a promising technique for visualizing mammals. However, the definition of the NIR-II region and the mechanism accounting for the excellent performance still need to be perfected. Herein, we simulate the photon propagation in the NIR region (to 2340 nm), confirm the positive contribution of moderate light absorption by water in intravital imaging and perfect the NIR-II window as 900-1880 nm, where 1400-1500 and 1700-1880 nm are defined as NIR-IIx and NIR-IIc regions, respectively. Moreover, 2080-2340 nm is newly proposed as the third near-infrared (NIR-III) window, which is believed to provide the best imaging quality. The wide-field fluorescence microscopy in the brain is performed around the NIR-IIx region, with excellent optical sectioning strength and the largest imaging depth of intravital NIR-II fluorescence microscopy to date. We also propose 1400 nm long-pass detection in off-peak NIR-II imaging whose performance exceeds that of NIR-IIb imaging, using bright fluorophores with short emission wavelength.
引用
收藏
页数:18
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