Chiral N,N′-dioxide-In(OTf)3-catalyzed asymmetric vinylogous Mukaiyama aldol reactions

被引：19
|
作者：
Fu, Kai [1 ]
Zheng, Jianfeng [1 ]
Lin, Lili [1 ]
Liu, Xiaohua [1 ]
Feng, Xiaoming [1 ,2 ]
机构：
[1] Sichuan Univ, Minist Educ, Coll Chem, Key Lab Green Chem & Technol, Chengdu 610064, Peoples R China
[2] Collaborat Innovat Ctr Chem Sci & Engn, Tianjin, Peoples R China
来源：
CHEMICAL COMMUNICATIONS | 2015年 / 51卷 / 15期
基金：
中国国家自然科学基金;
关键词：
LEWIS-BASE ACTIVATION; DIELS-ALDER REACTION; ADDITION-REACTIONS; KETENE ACETALS; ALDEHYDES; KETONES; FRAGMENT; LIGANDS; ACIDS; CALLIPELTOSIDE;
D O I：
10.1039/c4cc09820j
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Chiral N,N'-dioxide-In(OTf)(3) complexes were developed as efficient catalysts to catalyze the vinylogous Mukaiyama aldol reaction of the silyl dienol ester with aldehydes. The corresponding delta-hydroxy-alpha,beta-unsaturated esters were obtained in up to 99% yield and 98% ee. Moreover, the obtained (R)-3v can be easily transformed to natural bioactive products.
引用
收藏
页码：3106 / 3108
页数：3
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