Chiral N,N′-dioxide-In(OTf)3-catalyzed asymmetric vinylogous Mukaiyama aldol reactions

被引：19

作者：

Fu, Kai ^{[1
]}

Zheng, Jianfeng ^{[1
]}

Lin, Lili ^{[1
]}

Liu, Xiaohua ^{[1
]}

Feng, Xiaoming ^{[1
,2
]}

机构：

[1] Sichuan Univ, Minist Educ, Coll Chem, Key Lab Green Chem & Technol, Chengdu 610064, Peoples R China

[2] Collaborat Innovat Ctr Chem Sci & Engn, Tianjin, Peoples R China

来源：

CHEMICAL COMMUNICATIONS | 2015年 / 51卷 / 15期

基金：

中国国家自然科学基金;

关键词：

LEWIS-BASE ACTIVATION; DIELS-ALDER REACTION; ADDITION-REACTIONS; KETENE ACETALS; ALDEHYDES; KETONES; FRAGMENT; LIGANDS; ACIDS; CALLIPELTOSIDE;

D O I：

10.1039/c4cc09820j

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Chiral N,N'-dioxide-In(OTf)(3) complexes were developed as efficient catalysts to catalyze the vinylogous Mukaiyama aldol reaction of the silyl dienol ester with aldehydes. The corresponding delta-hydroxy-alpha,beta-unsaturated esters were obtained in up to 99% yield and 98% ee. Moreover, the obtained (R)-3v can be easily transformed to natural bioactive products.

引用

页码：3106 / 3108

页数：3

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