Synthesis of reduced-size gold nanostars and internalization in SH-SY5Y cells

被引：16

作者：

Dacarro, Giacomo ^{[1
]}

Pallavicini, Piersandro ^{[1
]}

Bertani, Serena Maria ^{[1
]}

Chirico, Giuseppe ^{[2
]}

D'Alfonso, Laura ^{[2
]}

Falqui, Andrea ^{[3
]}

Marchesi, Nicoletta ^{[4
]}

Pascale, Alessia ^{[4
]}

Sironi, Laura ^{[2
]}

Taglietti, Angelo ^{[1
]}

Zuddas, Efisio ^{[3
]}

机构：

[1] Univ Pavia, Dipartimento Chim, Vle Taramelli 12, I-27100 Pavia, Italy

[2] Univ Milano Bicocca, Dipartimento Fis G Occhialini, Piazza Sci 3, I-20126 Milan, Italy

[3] KAUST, Biol & Environm Sci & Engn BESE Div, NABLA Lab, Thuwal 239556900, Saudi Arabia

[4] Univ Pavia, Sez Farmacol, Dipartimento Sci Farmaco, Vle Taramelli 12, I-27100 Pavia, Italy

来源：

JOURNAL OF COLLOID AND INTERFACE SCIENCE | 2017年 / 505卷

关键词：

Nanostars; Nanoparticles; Gold; Cell internalization; HUMAN NEUROBLASTOMA-CELLS; WET CHEMICAL SYNTHESIS; IN-VITRO; CELLULAR UPTAKE; OPTICAL-PROPERTIES; ASPECT-RATIO; NANOPARTICLES; NANORODS; SURFACE; IR;

D O I：

10.1016/j.jcis.2017.06.102

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

The synthesis of large pentatwinned five-branched gold nanostars (GNS) has been modified so to obtain overall dimensions shrunk to 60% and a lower branches aspect ratio, leading to a dramatic blue shift of their two near-infrared (NIR) localized surface plasmon resonances (LSPR) absorptions but still maintaining one LSPR in the biotransparent NIR range. The interactions of polyethylene glycol (PEG) coated large and shrunk GNS with SH-SY5Y cells revealed that the large ones (DCI - diameter of the circumference in which GNS can be inscribed = 76 nm) are internalized more efficiently than the shrunk ones (DCI = 46 nm), correlating with a decreased cells surviving fraction. (C) 2017 Elsevier Inc. All rights reserved.

引用

页码：1055 / 1064

页数：10

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