Continuous synthesis of Gabapentin with a microreaction system

被引：30

作者：

Huang, Jin-Pei ^{[1
]}

Sang, Fu-Ning ^{[1
]}

Luo, Guang-Sheng ^{[1
]}

Xu, Jian-Hong ^{[1
]}

机构：

[1] Tsinghua Univ, State Key Lab Chem Engn, Dept Chem Engn, Beijing 100084, Peoples R China

来源：

CHEMICAL ENGINEERING SCIENCE | 2017年 / 173卷

基金：

中国国家自然科学基金;

关键词：

Gabapentin; Microreactor; Kinetic model; Process intensification; MICROSTRUCTURED REACTORS; KINETICS; CATALYST;

D O I：

10.1016/j.ces.2017.08.020

中图分类号：

TQ [化学工业];

学科分类号：

0817 ;

摘要：

In this paper, a microreaction system was developed to intensify the synthesis process of Gabapentin. Due to the high mass and heat transfer performance, Hofmann rearrangement can be achieved continuously by one-step microreaction process at relatively high temperature (40-45 degrees C) with a residence time (5-7 min) much shorter than the conventional 4-5 h in batch reactors. By studying the effects of concentration and temperature on the reaction rate, an apparent kinetic model was developed to help understanding the whole process deeply and optimizing the operation conditions. (C) 2017 Elsevier Ltd. All rights reserved.

引用

页码：507 / 513

页数：7

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