Short Report: Epidemiological Study of the Association between Anti-Lutzomyia longipalpis Saliva Antibodies and Development of Delayed-Type Hypersensitivity to Leishmania Antigen

被引：19

作者：

Aquino, Dorlene M. C. ^{[1
]}

Caldas, Arlene J. M. ^{[1
]}

Miranda, Jose Carlos ^{[2
]}

Silva, Antonio A. M. ^{[3
]}

Barral-Netto, Manoel ^{[4
,5
,6
]}

Barral, Aldina ^{[2
,5
,6
]}

机构：

[1] Univ Fed Maranhao, Dept Enfermagem, Sao Luis, Maranhao, Brazil

[2] Fundacao Oswaldo Cruz FIOCRUZ Bahia, CPqGM, Lab Imunoparasitol LIP, Salvador, BA, Brazil

[3] Univ Fed Maranhao, Dept Saude Publ, Sao Luis, Maranhao, Brazil

[4] Fundacao Oswaldo Cruz FIOCRUZ Bahia, CPqGM, Lab Imunoregulacao LIMI, Salvador, BA, Brazil

[5] Univ Fed Bahia, Fac Med, Salvador, BA, Brazil

[6] Inst Nacl Ciencia & Tecnol Invest Imunol III INCT, Salvador, BA, Brazil

来源：

AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE | 2010年 / 83卷 / 04期

关键词：

SAND FLY SALIVA; VISCERAL LEISHMANIASIS; IMMUNE-RESPONSE; CUTANEOUS LEISHMANIASIS; VECTOR SALIVA; INFECTION; BRAZILIENSIS; EXPOSURE; MODEL; MICE;

D O I：

10.4269/ajtmh.2010.10-0182

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

Recent reports from animal models and from cross-sectional studies have suggested that host responses to anti-Lutzomyia longipalpis saliva antibodies may be related to delayed-type hypersensitivity to Leishmania antigen. In a prospective cohort study, we evaluated 1,080 children from two endemic areas for visceral leishmaniasis (VL) by means of Kaplan-Meier analysis. The incidence rate of delayed-type hypersensitivity to Leishmania antigen, measured at the 24th follow-up month, was higher among those reactive to Lu. longipalpis saliva antibodies at the beginning of the study (0.0217 cases per person-month) than among those previously negative (0.0131 cases per person-month) (P value for the log-rank test = 0.0006). It seems that mounting an anti-saliva immune response helps the development of a cell-mediated anti-Leishmania response.

引用

页码：825 / 827

页数：3

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