Development of a Continuous-Flow Microreactor for Asymmetric Epoxidation of Electron-Deficient Olefins

被引：11

作者：

Dai, Wen

Mi, Yuan

Lv, Ying

Shang, Sensen

Li, Guosong

Chen, Guangwen ^{[1
]}

Gao, Shuang ^{[1
]}

机构：

[1] Chinese Acad Sci, Dalian Inst Chem Phys, Dalian 116023, Peoples R China

来源：

SYNTHESIS-STUTTGART | 2016年 / 48卷 / 16期

基金：

中国博士后科学基金;

关键词：

continuous flow; microreactor; asymmetric epoxidation; iron catalysis; electron-deficient olefins; biomimetic catalyst; HIGHLY STEREOSELECTIVE EPOXIDATION; ENANTIOSELECTIVE EPOXIDATION; HYDROGEN-PEROXIDE; ALPHA; BETA-UNSATURATED KETONES; CATALYSIS; ALKENES; OXIDATION; ORGANOCATALYSIS; COMPLEXES; SYSTEM;

D O I：

10.1055/s-0035-1561955

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Asymmetric epoxidation of electron-deficient olefins catalyzed by a biomimetic iron complex in a continuous-flow microreactor is described. The reaction conducted in the microreactor is characterized by rapid (<4 min) epoxidation of trisubstituted enones in high yields (up to 90%) and excellent enantioselectivities (up to 92% ee); compared to its batchwise counterpart, the microreactor reaction also allows shorter reaction times, safer operation, and more precise control over the reaction conditions.

引用

页码：2653 / 2658

页数：6

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