A hemicyanine complex for the detection of thiol biomolecules by fluorescence

被引：15

作者：

Doan Thanh Nhan ^{[1
]}

Nguyen Khoa Hien ^{[2
]}

Hoang Van Duc ^{[1
]}

Nguyen Thi Ai Nhung ^{[1
]}

Nguyen Tien Trung ^{[3
,4
]}

Dang Ung Van ^{[5
]}

Shin, Weon Sup ^{[6
]}

Kim, Jong Seung ^{[6
]}

Duong Tuan Quang ^{[1
,7
]}

机构：

[1] Hue Univ, Hue City 8454, Vietnam

[2] Vietnam Acad Sci & Technol, Mientrung Inst Sci Res, Hue City 8454, Vietnam

[3] Quy Nhon Univ, Dept Chem, Quy Nhon City 8456, Vietnam

[4] Quy Nhon Univ, Lab Computat Chem & Modelling, Quy Nhon City 8456, Vietnam

[5] Hoa Binh Univ, Hanoi 844, Vietnam

[6] Korea Univ, Dept Chem, Seoul 136701, South Korea

[7] Hue Coll Educ, Dept Chem, Hue City 8454, Vietnam

来源：

DYES AND PIGMENTS | 2016年 / 131卷

关键词：

Fluorescence; Hemicyanine; Thiol biomolecules; Ensemble complex; Cysteine; PERFORMANCE LIQUID-CHROMATOGRAPHY; AQUEOUS-SOLUTION; CYSTEINE; PROBE; GLUTATHIONE; HOMOCYSTEINE; CHEMOSENSOR; QUANTIFICATION; EMISSION; CELLS;

D O I：

10.1016/j.dyepig.2016.03.050

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Herein, we report the design and preparation of a benzothiazolium hemicyanine derivative that exhibits red emission at 585 nm. Its complex with Hg2+ may be used for selective and sensitive sensing of thiol biomolecules through the reversible visual color and florescence changes they induce in the complex. This complex was used to detect three test thiol biomolecules, and exhibited sensitivity in the order cysteine > glutathione > homocysteine. Furthermore, the complex allowed the detection of cysteine at 0.2 mu M, lower than the normal human intracellular cysteine concentration (30-200 mu M), and was found to be useable over at least five cycles upon alternate addition of cysteine and Hg2+. (C) 2016 Elsevier Ltd. All rights reserved.

引用

页码：301 / 306

页数：6

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