Rhodium-Catalyzed Remote C(sp3)-H Borylation of Silyl Enol Ethers

被引：41
|
作者：
Li, Jie [1 ]
Qu, Shuanglin [1 ]
Zhao, Wanxiang [1 ]
机构：
[1] Hunan Univ, Coll Chem & Chem Engn, State Key Lab Chemobiosensing & Chemometr, Changsha 410082, Hunan, Peoples R China
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2020年 / 59卷 / 06期
基金：
中国国家自然科学基金;
关键词：
borylation; C-H activation; isomerization; regioselectivity; rhodium; ALKENE ISOMERIZATION-HYDROBORATION; H BOND ACTIVATION; C-H; ENANTIOSELECTIVE ISOMERIZATION; BIFUNCTIONAL CATALYST; ALLYLIC ALCOHOLS; HECK ARYLATIONS; BORONIC ESTERS; CHAIN-WALKING; FUNCTIONALIZATION;
D O I：
10.1002/anie.201913281
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A rhodium-catalyzed remote C(sp(3))-H borylation of silyl enol ethers (SEEs, E/Z mixtures) by alkene isomerization and hydroboration is reported. The reaction exhibits mild reaction conditions and excellent functional-group tolerance. This method is compatible with an array of SEEs, including linear and branched SEEs derived from aldehydes and ketones, and provides direct access to a broad range of structurally diverse 1,n-borylethers in excellent regioselectivities and good yields. These compounds are precursors to various valuable chemicals, such as 1,n-diols and aminoalcohols.
引用
收藏
页码：2360 / 2364
页数：5
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